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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
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Limbal Stem Cell Deficiency Associated With Herpes Keratitis
Jimena Tatiana Carreno-Galeano1, Thomas H Dohlman, Jia Yin
1Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Cornea
|October 3, 2020
Summary
Herpes keratitis (HK) is a risk factor for limbal stem cell deficiency (LSCD). Patients with HK require monitoring for LSCD to prevent long-term ocular surface disease and vision loss.
Area of Science:
- Ophthalmology
- Corneal Diseases
- Infectious Eye Diseases
Background:
- Herpes keratitis (HK) is a common cause of corneal blindness.
- Limbal stem cell deficiency (LSCD) can lead to severe ocular surface disease and vision impairment.
Purpose of the Study:
- To investigate the demographic and clinical features of patients with HK and LSCD.
- To identify risk factors for developing LSCD following HK.
Main Methods:
- Retrospective case-series review of patients diagnosed with HK.
- Analysis of patient demographics, medical history, treatments, and visual acuity.
- Comparison of LSCD prevalence between herpes zoster keratitis and herpes simplex keratitis.
Main Results:
- 9.3% of HK patients developed LSCD.
- Herpes zoster keratitis, stromal involvement, and topical antihypertensive use were associated with higher LSCD risk.
- Patients with LSCD had significantly poorer visual acuity compared to those without LSCD.
Conclusions:
- HK is a potential risk factor for LSCD development.
- Regular monitoring for LSCD in HK patients is crucial for managing ocular surface health.
- Early detection and management of LSCD can mitigate chronic ocular morbidity.
