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Transcranial Direct Current Stimulation for Prader-Willi Syndrome.

Caroline C Azevedo1, Alisson Paulino Trevizol, July S Gomes1

  • 1From the Interdisciplinary Laboratory of Clinical Neroscience, Federal University of São Paulo, São Paulo, Brazil.

The Journal of ECT
|October 3, 2020
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Summary
This summary is machine-generated.

Transcranial direct current stimulation (tDCS) improved hyperphagia, food craving, and behavioral symptoms in Prader-Willi syndrome (PWS). This safe brain stimulation offers a promising, low-cost therapeutic option for PWS patients.

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Area of Science:

  • Neuroscience
  • Neurology
  • Medical Research

Background:

  • Prader-Willi syndrome (PWS) presents limited therapeutic avenues.
  • Hyperphagia, food craving, and aberrant behaviors are key challenges in PWS management.

Purpose of the Study:

  • To investigate the efficacy of transcranial direct current stimulation (tDCS) as a treatment for PWS symptoms.
  • To evaluate tDCS effects on hyperphagia, food craving, and behavioral issues in individuals with PWS.

Main Methods:

  • An open-label clinical trial involving twelve subjects with PWS (aged 11-35).
  • Administered 10 daily 20-minute tDCS sessions over two weeks.
  • Targeted left dorsolateral prefrontal cortex stimulation with anode and cathode placement.

Main Results:

  • Significant amelioration of hyperphagic and food craving symptoms (P < 0.05).
  • Observed significant improvements in behavioral symptoms, as measured by the Aberrant Behavior Checklist (P < 0.05).

Conclusions:

  • This proof-of-concept trial demonstrates tDCS's positive impact on PWS symptoms.
  • tDCS offers a safe, low-cost, and effective brain stimulation approach for PWS.
  • Increased left dorsolateral prefrontal cortex excitability may alleviate core PWS challenges.