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Accelerating in vivo fast spin echo high angular resolution diffusion imaging with an isotropic resolution in mice

Maarten Naeyaert1, Jan Aelterman2, Johan Van Audekerke1

  • 1Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium.

Magnetic Resonance in Medicine
|October 3, 2020
PubMed
Summary

Accelerating Fast Spin Echo (FSE) imaging with compressed sensing allows for high angular resolution diffusion imaging (HARDI) acquisition times comparable to Echo Planar Imaging (EPI). This method enables replicable quantitative measurements in mice, minimizing artifacts near sensitive areas.

Keywords:
HARDIcompressed sensingdiffusionfast spin echoturbo spin echo

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Area of Science:

  • Neuroimaging
  • Diffusion MRI
  • Image Reconstruction

Background:

  • Echo planar imaging (EPI) is standard for high angular resolution diffusion imaging (HARDI) but prone to artifacts.
  • Fast spin echo (FSE) offers fewer artifacts but is slower.
  • Compressed sensing (CS) is explored to accelerate FSE for HARDI.

Purpose of the Study:

  • To accelerate FSE imaging for HARDI acquisition within a time frame similar to EPI.
  • To evaluate the efficacy of compressed sensing in accelerating FSE for HARDI.
  • To assess the replicability and quantitative accuracy of accelerated FSE-HARDI.

Main Methods:

  • Compressed sensing applied in q-space and/or k-space with undersampling.
  • Acquisition and reconstruction of HARDI data from six mice and a numerical phantom.
  • Analysis using constrained spherical deconvolution, evaluating apparent fiber density and complexity, and tractography.

Main Results:

  • Q-space undersampling alone showed minor impact on metrics.
  • K-space undersampling led to metric deterioration and information loss.
  • Good results for tract density weighted images with ≥15 diffusion directions using q-space undersampling.

Conclusions:

  • Acquiring 15-20 diffusion directions with full k-space and CS reconstruction is sufficient for replicable quantitative HARDI measures in mice.
  • This accelerated FSE-HARDI approach yields artifact-free results in regions near sinuses and ear cavities.