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Related Concept Videos

Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Pooled CRISPR-Based Genetic Screens in Mammalian Cells
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CRISP-view: a database of functional genetic screens spanning multiple phenotypes.

Yingbo Cui1, Xiaolong Cheng2, Qing Chen2

  • 1Sanyi Road, Changsha, Hunan Province, People's Republic of China.

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|October 3, 2020
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Summary

CRISP-view is a new database integrating CRISPR/Cas9 and RNA interference screening data. It aids in understanding gene functions and genotype-to-phenotype relationships across various biological processes.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • High-throughput genetic screening using CRISPR/Cas9 and RNA interference (RNAi) is crucial for large-scale gene exploration.
  • Publicly available genetic screening data offers extensive insights into genotype-to-phenotype relationships and gene functions.

Purpose of the Study:

  • To present CRISP-view, a comprehensive database consolidating CRISPR/Cas9 and RNAi screening datasets.
  • To provide a centralized resource for exploring diverse phenotypes, including cell proliferation, cancer immunotherapy response, and viral response.

Main Methods:

  • Collected and curated 10,321 human and 825 mouse samples from 167 publications (as of September 22, 2020).
  • Processed all datasets using the standard MAGeCK-VISPR analysis pipeline with rigorous quality control (QC) metrics.
  • Developed a user-friendly webserver for intuitive visualization, exploration, and searching of the integrated datasets.

Main Results:

  • CRISP-view encompasses a wide array of phenotypes, covering in vitro and in vivo studies.
  • The database provides standardized analysis and QC metrics for all integrated screening data.
  • A webserver facilitates easy access and analysis of the genetic screening datasets.

Conclusions:

  • CRISP-view serves as a valuable resource for researchers investigating gene functions and genotype-to-phenotype links.
  • The integrated datasets and user-friendly webserver streamline the analysis of CRISPR/Cas9 and RNAi screening data.
  • This database promotes systematic exploration of genetic determinants across various biological contexts.