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Related Concept Videos

Genetic Screens02:46

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Updated: Dec 6, 2025

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics.

Emily Swanzey1, Callan O'Connor2, Laura G Reinholdt1

  • 1The Jackson Laboratory, Bar Harbor, ME, USA.

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|October 4, 2020
PubMed
Summary
This summary is machine-generated.

Genetically diverse mouse cell models reveal how genetic variations impact cellular traits. These systems enable disease modeling and discovery of gene functions for better understanding of cellular identity.

Keywords:
collaborative crossdiversity outbredgenetic reference populationintegrative genomicsquantitative trait locussystems genetics

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Area of Science:

  • Genetics
  • Cell Biology
  • Systems Biology

Background:

  • Cellular and molecular traits are key to understanding disease.
  • Genetically diverse cell populations offer powerful tools for biological research.
  • In vitro systems genetics approaches leverage these populations to study cellular function and identity.

Purpose of the Study:

  • To review mouse cellular systems genetics approaches.
  • To characterize the influence of genetic variation on cellular signaling networks and phenotypic diversity.
  • To discuss data integration and cross-species validation strategies.

Main Methods:

  • Utilizing primary cells, stem cells, and organoids from genetically diverse mouse strains (Collaborative Cross, Diversity Outbred).
  • Employing parallel in vitro/in vivo screening.
  • Leveraging genetic resolution for variant discovery and functional characterization.

Main Results:

  • Genetically diverse cell panels provide significant genetic resolution.
  • These systems facilitate disease modeling and in vivo validation.
  • The approaches allow for characterization of genetic variation's impact on cellular phenotypes.

Conclusions:

  • Mouse cellular systems genetics is crucial for dissecting genetic influences on cellular traits.
  • These models are valuable for disease research, variant discovery, and functional genomics.
  • Integration of data and cross-species validation are key for advancing the field.