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Related Experiment Videos

Hirsutism.

W F Bergfeld, G P Redmond

    Dermatologic Clinics
    |July 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Diagnosing hirsutism involves assessing androgen levels, with initial screening using dehydroepiandrosterone sulfate (DHEA-S) and free testosterone. Further tests and targeted therapies depend on identifying the source of androgen excess, whether adrenal or ovarian.

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    Area of Science:

    • Endocrinology
    • Dermatology
    • Reproductive Medicine

    Background:

    • Hirsutism diagnosis requires assessing androgen status.
    • Current diagnostic techniques involve multiple, often expensive, tests.

    Purpose of the Study:

    • To outline a diagnostic approach for hirsutism.
    • To differentiate between ovarian and adrenal androgen hypersecretion.
    • To guide targeted antiandrogen therapy selection.

    Main Methods:

    • Initial screening with dehydroepiandrosterone sulfate (DHEA-S) and total free testosterone.
    • Further testing including 17-hydroxyprogesterone, prolactin, compound S, cortisol, and dexamethasone suppression test if indicated.
    • Evaluating androgen-dependent cutaneous syndromes and potential enzymatic defects.

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    Main Results:

    • Elevated androgens indicate hypersecretion, with testosterone elevations potentially originating from ovaries or adrenals.
    • Identifying the source of excess androgens allows for selective antiandrogen therapy.
    • Adrenal hypersecretion may respond to adrenal suppression (e.g., dexamethasone); ovarian hypersecretion may benefit from cyclic estrogens.

    Conclusions:

    • A comprehensive evaluation of hirsutism requires time, expertise, and knowledge of androgen metabolism.
    • Referral to an endocrinologist is recommended if the dermatologist lacks the necessary expertise.
    • Accurate diagnosis facilitates effective, targeted treatment for hirsute patients.