Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

662
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
662
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

466
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
466
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

670
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
670
SBAR II: Application of SBAR01:14

SBAR II: Application of SBAR

5.4K
SBAR is an effective communication tool used by healthcare professionals to communicate patient information accurately. SBAR stands for Situation, Background, Assessment, and Recommendation. For a better understanding, an example is given below.
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
5.4K
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

4.3K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.3K
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

425
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
425

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aortic shape with high-acute isthmic angle post frozen elephant trunk reconstruction is associated with worse postoperative outcomes: Multisite, principal component analysis, retrospective study.

JTCVS structural and endovascular·2026
Same author

Early cardiometabolic dysfunction: subclinical indicators and sex-specific considerations.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Ethical Challenges of Extracorporeal Membrane Oxygenation: Enhanced Recovery After Surgery Cardiac Society Consensus on Key Issues and Practical Recommendations.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

The Preoperative Role of Right-Sided Heart Function in Primary Graft Dysfunction After Bilateral Lung Transplantation.

The Annals of thoracic surgery·2026
Same author

Factors associated with native heart survival and intermediate-term outcomes in acute myocardial infarction-related cardiogenic shock.

European heart journal open·2026
Same author

Column, Line-of-Sight, Margins, Ring: A Framework for Planning En Bloc Spondylectomies.

Operative neurosurgery (Hagerstown, Md.)·2026
Same journal

Relationship between spontaneous EEG oscillations at 7 and 45 days of acute plateau exposure and the plateau acclimatization index.

Frontiers in neuroscience·2026
Same journal

Neuroprotective effects of paederoside against mitochondrial dysfunction in rotenone-induced cell models of Parkinson's disease.

Frontiers in neuroscience·2026
Same journal

Covariance-based analysis of spindle-band EEG during declarative and non-declarative odor cueing in sleep.

Frontiers in neuroscience·2026
Same journal

Correction: Physiological determinants of cortical P100 responses in pattern visual evoked potentials: a scoping review.

Frontiers in neuroscience·2026
Same journal

Transcranial magnetic stimulation and motor overflow: a systematic review in neurological disorders.

Frontiers in neuroscience·2026
Same journal

Editorial: Advancing neurodegenerative disease biomarkers: the role of neuroimaging in TDP-43 and tau proteinopathies.

Frontiers in neuroscience·2026
See all related articles

Related Experiment Video

Updated: Dec 6, 2025

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

9.6K

Lactate-Protected Hypoglycemia (LPH).

Matthew L Goodwin1, L Bruce Gladden2, Maarten W N Nijsten3

  • 1Department of Orthopedic Surgery, Washington University in St. Louis, St. Louis, MO, United States.

Frontiers in Neuroscience
|October 5, 2020
PubMed
Summary
This summary is machine-generated.

Lactate-protected hypoglycemia (LPH) targets tumors by altering glucose and lactate levels. This approach leverages lactate as a fuel source for the central nervous system, potentially treating brain and spinal cord pathologies.

Keywords:
hyperlactatemiahypoglycemialactatelactate dehydrogenasemonocarboxylate transportershuttle

More Related Videos

Measuring Lactase Enzymatic Activity in the Teaching Lab
04:41

Measuring Lactase Enzymatic Activity in the Teaching Lab

Published on: August 6, 2018

116.1K
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.2K

Related Experiment Videos

Last Updated: Dec 6, 2025

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

9.6K
Measuring Lactase Enzymatic Activity in the Teaching Lab
04:41

Measuring Lactase Enzymatic Activity in the Teaching Lab

Published on: August 6, 2018

116.1K
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.2K

Area of Science:

  • Biochemistry
  • Oncology
  • Neuroscience

Background:

  • The Warburg effect describes tumor glucose consumption and lactate production.
  • Some tumors may utilize lactate as a fuel source (reverse Warburg effect).
  • Tumor response to altered lactate and glucose levels in vivo remains unclear.

Purpose of the Study:

  • To explore the concept of lactate-protected hypoglycemia (LPH) for tumor targeting.
  • To investigate the potential of manipulating lactate and glucose for cancer therapy.
  • To identify novel therapeutic strategies for brain and spinal cord pathologies.

Main Methods:

  • Review of experimental and observational evidence.
  • Discussion of targeting lactate transport and metabolism.
  • Consideration of combined interventions: altered glucose/lactate concentrations and transport inhibitors.

Main Results:

  • Lactate can serve as a crucial salvage fuel for the central nervous system.
  • Tumors exhibit diverse metabolic behaviors, including the Warburg effect and potential reverse Warburg effect.
  • The in vivo behavior of tumors under perturbed lactate and glucose conditions requires further investigation.

Conclusions:

  • Lactate-protected hypoglycemia presents a novel strategy for targeting tumors.
  • Exploiting lactate transport and metabolism offers potential for treating difficult brain and spinal cord pathologies.
  • Further research is needed to develop effective LPH-based therapies.