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Non-coding RNAs in Cardiac Intercellular Communication.

Raquel Figuinha Videira1,2,3, Paula A da Costa Martins1,2,4

  • 1CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands.

Frontiers in Physiology
|October 5, 2020
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) within extracellular vesicles (EVs) mediate intercellular communication. Altered exosomal ncRNAs contribute to cardiac remodeling and heart failure, highlighting their potential as therapeutic targets.

Keywords:
cardiac intercellular communicationcardiac pathological remodelingextracellular vesiclesheart failurenon-coding RNAs

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Area of Science:

  • Molecular Biology
  • Cardiovascular Research
  • Cellular Communication

Background:

  • Intercellular communication is vital for maintaining tissue homeostasis, with alterations contributing to pathological conditions like cardiac remodeling.
  • Extracellular vesicles (EVs), including exosomes, are key mediators of cell-to-cell communication, transporting various molecules.
  • Non-coding RNAs (ncRNAs) carried by EVs are crucial regulators of physiological and pathological cellular processes.

Purpose of the Study:

  • To review the current research on the role of ncRNAs in intercellular communication.
  • To explore the specific involvement of ncRNAs within EVs in cardiac pathological remodeling.
  • To discuss the therapeutic potential of targeting exosomal ncRNAs for cardiac dysfunction.

Main Methods:

  • Literature review of existing research on ncRNAs, EVs, and cardiac remodeling.
  • Analysis of studies investigating the cargo and function of ncRNAs in exosomes.
  • Synthesis of findings related to ncRNA-mediated intercellular communication in cardiac disease models.

Main Results:

  • Exosomal ncRNAs are functionally active and can trigger remodeling events in recipient cardiac cells.
  • Cardiac injury leads to changes in exosomal ncRNAs that promote hypertrophic growth, fibrosis, inflammation, and endothelial dysfunction.
  • Altered profiles of ncRNAs in EVs are linked to cardiac dysfunction and progression to heart failure.

Conclusions:

  • Exosomal ncRNAs play a critical role in the pathogenesis of cardiac pathological remodeling.
  • Modulating the presence or activity of exosomal ncRNAs may offer a strategy to attenuate cardiac dysfunction.
  • Exosomal ncRNAs represent promising novel therapeutic targets for heart failure and related cardiovascular diseases.