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Outcomes of Patients With Hypothyroidism and COVID-19: A Retrospective Cohort Study

Maaike van Gerwen1,2, Mathilda Alsen1, Christine Little1

  • 1Department of Otolaryngology- Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Frontiers in Endocrinology
|October 5, 2020
PubMed

Insights

Pre-existing hypothyroidism did not increase the risk of severe outcomes in COVID-19 patients. This study found no significant association between hypothyroidism and hospitalization, mechanical ventilation, or mortality in coronavirus disease patients.

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Public Health

Background:

  • Coronavirus disease (COVID-19) is linked to significant morbidity and mortality.
  • The effect of pre-existing hypothyroidism on COVID-19 outcomes is not well understood.
  • Understanding comorbidities' impact is crucial for managing COVID-19 patients.

Purpose of the Study:

  • To investigate the association between pre-existing hypothyroidism and COVID-19 outcomes.
  • To determine if hypothyroidism influences hospitalization, mechanical ventilation, or mortality rates.
  • To inform clinical management strategies for COVID-19 patients with hypothyroidism.

Main Methods:

  • Retrospective review of 3703 COVID-19 positive patients diagnosed in March 2020.
  • Analysis of outcomes including hospitalization, mechanical ventilation, and all-cause mortality.
  • Statistical analysis comparing outcomes in patients with and without pre-existing hypothyroidism.

Main Results:

  • Of 3703 patients, 251 (6.8%) had pre-existing hypothyroidism on thyroid hormone therapy.
  • Hypothyroidism was not significantly associated with increased hospitalization risk (ORadj: 1.23, 95% CI: 0.88-1.70).
  • No significant association was found for mechanical ventilation (ORadj: 1.17, 95% CI: 0.81-1.69) or all-cause mortality (ORadj: 1.07, 95% CI: 0.75-1.54).

Conclusions:

  • Pre-existing hypothyroidism does not appear to worsen outcomes in COVID-19 patients.
  • No additional precautions or consultations are currently indicated for COVID-19 patients with hypothyroidism.
  • Further research is needed on COVID-19's potential effects on thyroid function and gland.

Keywords:
COVID-19cohortepidemiologyhypothyroidismoutcomessurvival

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