Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Computed Tomography01:10

Computed Tomography

7.7K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
7.7K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

167
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
167
Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

8.4K
Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
8.4K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

987
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
987
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

861
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
861

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drusen volume and reticular pseudodrusen volume from optical coherence tomography with deep learning as risk factors for progression to late age-related macular degeneration in eyes with reticular pseudodrusen and contralateral macular neovascularisation.

The British journal of ophthalmology·2026
Same author

Histology correlated adaptive optics polarisation sensitive optical coherence tomography.

Biomedical optics express·2026
Same author

AI-aided segmentation of four types of drusen in volumetric OCT.

Biomedical optics express·2025
Same author

Deep reinforcement learning for automatic defocus correction using OCT image intensity.

Biomedical optics express·2025
Same author

Quantification of intermittent retinal capillary perfusion in retinal vein occlusion and proliferative diabetic retinopathy.

International journal of retina and vitreous·2025
Same author

An eyecare foundation model for clinical assistance: a randomized controlled trial.

Nature medicine·2025
Same journal

Generalizable framework for multi-site bone density prediction using non-dominant wrist optical biomarkers.

Biomedical optics express·2026
Same journal

Erratum: Review of dynamic optical coherence tomography for intracellular motility [Invited]: errata.

Biomedical optics express·2026
Same journal

Digital-micromirror-device-based illumination strategies for background suppression in single-molecule localization microscopy.

Biomedical optics express·2026
Same journal

Synergistic combination of convective self-assembly and hollow core fiber for sensitive SERS detection of glucose molecules.

Biomedical optics express·2026
Same journal

Multimodal diagnostic network integrating infrared and mass spectra for lung cancer.

Biomedical optics express·2026
Same journal

Multimodal Optical Biosensing for Precision Medicine and Healthcare: Introduction to the feature issue.

Biomedical optics express·2026
See all related articles

Related Experiment Video

Updated: Dec 6, 2025

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

8.8K

Sensorless adaptive-optics optical coherence tomographic angiography.

Acner Camino1, Pengxiao Zang1, Arman Athwal2

  • 1Casey Eye Institute, Oregon Health & Science University, Portland, OR 27239, USA.

Biomedical Optics Express
|October 5, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a new sensorless adaptive optics optical coherence tomographic angiography (AO-OCTA) system. It achieves high-resolution retinal imaging over a larger field of view, improving visualization of small blood vessels for potential clinical use.

More Related Videos

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
11:21

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

11.8K
Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

19.1K

Related Experiment Videos

Last Updated: Dec 6, 2025

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

8.8K
Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
11:21

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

11.8K
Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

19.1K

Area of Science:

  • Ophthalmic imaging
  • Biomedical optics
  • Retinal vasculature imaging

Background:

  • Optical coherence tomographic angiography (OCTA) visualizes retinal blood flow but is limited by low lateral resolution.
  • Adaptive optics (AO) enhances resolution by correcting ocular aberrations, but previous AO-OCTA systems had limited fields of view (FOV) and complexity.
  • Small FOV in prior AO-OCTA hinders clinical biomarker extraction.

Purpose of the Study:

  • To develop a sensorless AO-OCTA prototype with an intermediate numerical aperture.
  • To achieve high-resolution, depth-resolved angiograms over a clinically relevant FOV.
  • To improve the trade-off between resolution and FOV compared to existing AO-OCTA systems.

Main Methods:

  • Developed a sensorless AO-OCTA prototype with intermediate NA.
  • Utilized real-time retinal layer segmentation for aberration correction (defocus, astigmatism, coma).
  • Achieved AO correction and optimized focusing in 1.35 seconds.

Main Results:

  • Produced high-resolution (6 µm focal spot) and high signal-to-noise ratio angiograms over a 2x2 mm FOV.
  • Demonstrated finer capillary caliber visualization compared to commercial OCTA systems.
  • Reduced projection artifacts in deep and intermediate capillary plexuses.

Conclusions:

  • The developed AO-OCTA prototype offers improved image quality (resolution, SNR, capillary detail) without sacrificing FOV or adding excessive complexity.
  • This system shows potential for clinical translation in retinal imaging.
  • The intermediate NA and sensorless AO approach provide a favorable balance for biomarker discovery.