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Remdesivir-COVID-19: drug interactions in dentistry
1Department of Medically Compromised Patients in Dentistry, School of Dentistry, University of Granada, Granada, Spain. ggomez@ugr.es.
Dentists must be aware of moderate drug interactions between remdesivir and common dental medications like antibiotics and NSAIDs. This knowledge is crucial for preventing adverse events in COVID-19 patients undergoing treatment.
Area of Science:
- Pharmacology
- Infectious Diseases
- Dentistry
Background:
- Remdesivir is a nucleotide analogue prodrug with broad-spectrum antiviral activity against RNA viruses.
- It is recognized as a potential therapeutic agent for treating COVID-19.
- Potential drug interactions require careful consideration to ensure patient safety.
Purpose of the Study:
- To identify dental drugs that interact with remdesivir.
- To prevent adverse drug reactions in COVID-19 patients receiving remdesivir.
- To inform oral health professionals about potential interactions.
Main Methods:
- A literature review was conducted up to July 31, 2020.
- Databases searched included PubMed and MEDLINE.
- Key terms were remdesivir, drug interactions, and dentistry.
Main Results:
- A total of 279 drugs interact with remdesivir.
- All identified interactions with dental drugs were classified as moderate.
- Interacting dental drug classes include antibiotics, antifungals, and NSAIDs.
Conclusions:
- Oral health professionals must be aware of remdesivir drug interactions.
- Preventing adverse reactions is critical for patient safety.
- Awareness can mitigate life-threatening complications in COVID-19 patients.
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