The impact of the uncertainty of biological tissue thermal parameters on the estimated maximum temperature during TTFields treatment

In this work we evaluated the maximum temperature reached by the head tissues and transducers during TTFields treatment when the thermal parameters were changed. We used Pennes' equation to obtain the temperature distribution and we ran our studies using COMSOL Multiphysics. We observed that, among the parameters we tested, changes in the scalp thermal conductivity and grey matter blood perfusion were the ones that led to the highest temperature variations.Clinical Relevance- This work shows that the uncertainty regarding the thermal parameters of biological tissues might lead to significant changes in the temperature distribution when modeling heat transfer during TTFields therapy.