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Articles linked to this work by shared authors, journal, and citation graph.

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The influence of body mass index on Tumor Treating Fields therapy in patients with metastatic non-small cell lung cancer: A post-hoc and simulation analysis from the phase III LUNAR study.

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Temperature and Impedance Variations During Tumor Treating Fields (TTFields) Treatment.

Nichal Gentilal1, Eyal Abend2, Ariel Naveh2

  • 1Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, Lisbon, Portugal.

Frontiers in Human Neuroscience
|July 28, 2022
PubMed
Summary

Tumor Treating Fields (TTFields) for glioblastoma can cause scalp heating and head impedance changes. Optimal array placement, at least 1 cm apart, is suggested to maintain treatment efficacy and account for these variations.

Keywords:
NovoTAL systemTumor Treating Fields (TTFields)finite element method (FEM)glioblastoma multiforme (GBM)head impedancerealistic head modeltissue heating

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Area of Science:

  • Biomedical Engineering
  • Computational Electromagnetics
  • Oncology

Background:

  • Tumor Treating Fields (TTFields) are FDA-approved for glioblastoma multiforme (GBM).
  • TTFields use low-intensity electric fields to disrupt cancer cell mitosis.
  • Scalp heating (Joule effect) and head impedance changes occur during TTFields treatment.

Purpose of the Study:

  • Investigate realistic scalp temperature increases during TTFields therapy.
  • Quantify the impact of temperature and impedance variations on optimal array placement.
  • Analyze head impedance variations using clinical trial data.

Main Methods:

  • Utilized a realistic head model with NovoTAL™ system array positions.
  • Performed computational simulations to assess temperature distribution.
  • Analyzed patient log files from the EF-14 clinical trial for impedance data.

Main Results:

  • Close array placement (<1 cm) created hotspots, limiting current injection and potentially reducing efficacy.
  • Scalp temperature increases due to Joule effect are significant.
  • Head impedance variations are influenced by long-term changes, array placement, and circadian rhythms.

Conclusions:

  • Array placement should maintain at least 1 cm separation to avoid hotspots and ensure treatment efficacy.
  • Accounting for both temperature and impedance variations is crucial for accurate TTFields computational modeling.
  • Understanding these physiological changes can optimize TTFields treatment planning.