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Flow Cytometry Analysis of Immune Cells Within Murine Aortas
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A strobe multicenter descriptive study of 55 infectious aortitis.

Louis Journeau1,2, Marine de la Chapelle3, Thomas Guimard4

  • 1Department of Internal Medicine, Hôpital Louis Mourier (AP-HP), Colombes.

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Infectious aortitis (IA) is a severe condition with diverse microbial causes. Open surgery remains the primary treatment, but further research is needed to evaluate endovascular repair options for IA.

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Area of Science:

  • Vascular Surgery
  • Infectious Diseases
  • Radiology

Background:

  • Infectious aortitis (IA) is a rare but serious condition often treated with open surgery and antibiotics.
  • Previous studies on IA microbiology and treatment are limited.

Purpose of the Study:

  • To describe the clinical features, microbiological profiles, and treatment outcomes of a large cohort of patients with infectious aortitis.
  • To evaluate the role of different diagnostic tools and surgical approaches in managing IA.

Main Methods:

  • A retrospective, multicenter study of native aorta IA cases from 2000 to 2019.
  • Inclusion criteria included confirmed microorganism presence and imaging-defined aortic structural anomaly.
  • Data collected on patient demographics, microbiology, IA location, treatment (medical and surgical), and outcomes.

Main Results:

  • 55 patients (85% male, median age 65) were included.
  • Microbiology revealed a wider range of pathogens than previously reported, including Gram-negative rods, Gram-positive cocci, and fastidious organisms like Coxiella burnetii.
  • Abdominal IA was most common (56%), followed by thoracic (27%) and thoraco-abdominal (16%). Open surgery was the predominant treatment (41 patients), with limited use of endovascular aneurysm repair (4 patients).
  • Mortality at 1-month follow-up was 16% (9 patients), with no significant difference based on germ type or IA location.

Conclusions:

  • The spectrum of microorganisms causing IA is expanding.
  • Positron emission tomography-computed tomography (PET-CT) is a valuable diagnostic tool.
  • Open surgery is the current standard, but further prospective studies are needed to clarify the role of endovascular aneurysm repair in IA management.