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Updated: Dec 6, 2025
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Chronic Kidney Disease as Risk Factor for Enlarged Perivascular Spaces in Patients With Stroke and Relation to Racial
Ashley A Penton1, Helena Lau1, Viken L Babikian1,2
1Department of Neurology, Boston University School of Medicine, MA (A.A.P., H.L., V.L.B., J.S., A.C.-A., S.G., D.G., H.J.A., J.R.R.).
Stroke
|October 6, 2020
Summary
Chronic kidney disease (CKD) is linked to enlarged perivascular spaces (EPVS), a marker of small vessel disease. This association varies significantly by race and brain region, suggesting race-specific impacts on cerebrovascular health.
Area of Science:
- Neurology
- Nephrology
- Radiology
Background:
- Enlarged perivascular spaces (EPVS) are subclinical markers of small vessel disease, associated with stroke and dementia risk.
- Chronic kidney disease (CKD) is increasingly recognized as a contributor to small vessel disease.
Purpose of the Study:
- To investigate the relationship between CKD and EPVS burden.
- To explore how racial group influences the association between CKD and EPVS.
Main Methods:
- A cohort of 894 stroke patients undergoing brain MRI was analyzed.
- CKD was defined by estimated glomerular filtration rate <60 mL/minute/1.73 m² for >3 months.
- EPVS were assessed, dichotomized (mild vs. severe), and stratified by brain region (basal ganglia, centrum semiovale).
Main Results:
- CKD was associated with severe EPVS in the centrum semiovale.
- The CKD-EPVS association differed across racial groups.
- Black patients with CKD showed higher odds of severe EPVS in basal ganglia and centrum semiovale compared to White and other racial groups.
Conclusions:
- CKD prevalence was higher in stroke patients with severe centrum semiovale EPVS.
- The relationship between CKD and EPVS is influenced by race and brain region.
- Further research is needed to elucidate race-specific effects of CKD on small vessel disease markers.
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