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Updated: Dec 6, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

11.2K

SETD2 as a regulator of N6-methyladenosine RNA methylation and modifiers in cancer

Subhadra Kumari1, Srinivasan Muthusamy

  • 1Department of Life Science, National Institute of Technology, Rourkela, India.

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
|October 6, 2020
PubMed

Insights

Mutations in the SETD2 gene impact cancer development by altering RNA methylation. Loss of SETD2 function is linked to aggressive cancer phenotypes and worse patient prognosis.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Cancer involves genetic and epigenetic alterations.
  • SETD2 gene mutations are common in various cancers.
  • SETD2 plays roles in RNA splicing, DNA repair, and methylation.

Purpose of the Study:

  • To review the role of SETD2 in RNA methylation and modification.
  • To elucidate how SETD2 mutations contribute to tumor development.

Main Methods:

  • Literature review of studies on SETD2 function and cancer.
  • Analysis of the link between SETD2, histone modification, and mRNA methylation.
  • Examination of the impact of SETD2 mutations on cancer prognosis.

Main Results:

  • SETD2 catalyzes H3K36 trimethylation, which guides m6A RNA methylation.
  • Loss of SETD2 is associated with aggressive cancer phenotypes and poor prognosis.
  • SETD2 mutations disrupt normal RNA metabolism and contribute to tumorigenesis.

Conclusions:

  • SETD2 is crucial for epigenetic regulation and RNA metabolism.
  • Altered SETD2 function due to mutations significantly impacts cancer progression.
  • Understanding SETD2's role offers potential therapeutic targets for cancer treatment.

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