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A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
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A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

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RNA N6-methyladenosine modification in regulating cancer stem cells and tumor immune microenvironment and its

Subhadra Kumari1, Santosh Kumar1, Srinivasan Muthuswamy2

  • 1Department of Life Science, National Institute of Technology, Rourkela, India.

Journal of Cancer Research and Clinical Oncology
|July 7, 2022
PubMed

Insights

Cancer stem cells (CSCs) drive therapy resistance by altering RNA modifications. Targeting these RNA N6-methyladenosine (m6A) pathways offers new strategies for cancer treatment and diagnosis.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Therapy resistance is a major challenge in cancer treatment, leading to relapse and mortality.
  • Cancer stem cells (CSCs) are key drivers of drug resistance and tumor recurrence.
  • Dysregulated RNA N6-methyladenosine (m6A) modifications are observed in drug-resistant cancer cells.

Purpose of the Study:

  • To review the role of m6A modifiers in CSC generation, proliferation, and therapy resistance.
  • To explore the interplay between m6A modifications, CSCs, and the tumor immune microenvironment (TIME).
  • To discuss the therapeutic potential of targeting the m6A machinery in cancer.

Main Methods:

  • Literature review focusing on m6A RNA modifications and cancer stem cells.
  • Analysis of signaling pathways influenced by the tumor microenvironment.
  • Examination of epigenetic changes related to drug resistance.

Main Results:

  • m6A modifiers play a crucial role in CSC generation and maintenance.
  • Aberrant m6A levels contribute to cancer cell survival and therapy resistance.
  • m6A modifications influence the cross-talk between CSCs and the TIME.

Conclusions:

  • Targeting m6A machinery presents a promising therapeutic strategy for overcoming cancer drug resistance.
  • Understanding m6A regulation in CSCs can lead to novel diagnostic and therapeutic approaches.
  • m6A modification is a critical factor in cancer progression and treatment outcomes.
Keywords:
CancerCancer stem cellsPrognosisRecurrenceTherapy resistanceTumor immune microenvironmentm6A modification

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