Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

111
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
111
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

170
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
170
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

274
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
274
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

148
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
148
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

242
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
242
Thoracic Aorta01:15

Thoracic Aorta

1.2K
The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The IRE1α Pathway Links Endoplasmic Reticulum Stress to Atherosclerosis-Related Inflammation and Lipid Accumulation.

Mediators of inflammation·2026
Same author

Lipoprotein(a) Concentration and Achieving Target Values of Low-Density Lipoprotein Cholesterol Calculated by Different Equations.

Diseases (Basel, Switzerland)·2026
Same author

The Role of Testosterone in Atherosclerosis: View From Cell Cultures and Animal Models.

Journal of cardiovascular translational research·2026
Same author

Gut and oral microbiome profiles in patients with obesity and ischemic heart disease.

Frontiers in cellular and infection microbiology·2025
Same author

The Impact of Lipoprotein Apheresis on Inflammatory Factors: A Systematic Review and Meta-Analysis.

Journal of clinical apheresis·2025
Same author

Role of Lipoprotein(a) and Blood Cells Ratios in Peripheral Artery Disease.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Dec 6, 2025

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

687

Thoracic Aortic Aneurysm and Factors Affecting Aortic Dissection.

Petr V Chumachenko1, Anton Yu Postnov1,2, Alexandra G Ivanova3

  • 1Laboratory of Medical Genetics, National Medical Research Center of Cardiology, Institute of Experimental Cardiology, 15-a 3-rd Cherepkovskaya Str., 121552 Moscow, Russia.

Journal of Personalized Medicine
|October 7, 2020
PubMed
Summary

Inflammation and new blood vessel growth in the aortic aneurysm wall are linked to dissection. Lipoprotein (a) was rarely found in thoracic aortic aneurysm biopsies.

Keywords:
dissectioninflammationlipoprotein(a)medianecrosesthoracic aortic aneurysmvasa vasorum

More Related Videos

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

623
Author Spotlight: Using Point-of-Care Ultrasound for Comprehensive Evaluation of the Abdominal Aorta
07:12

Author Spotlight: Using Point-of-Care Ultrasound for Comprehensive Evaluation of the Abdominal Aorta

Published on: September 8, 2023

3.8K

Related Experiment Videos

Last Updated: Dec 6, 2025

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

687
Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

623
Author Spotlight: Using Point-of-Care Ultrasound for Comprehensive Evaluation of the Abdominal Aorta
07:12

Author Spotlight: Using Point-of-Care Ultrasound for Comprehensive Evaluation of the Abdominal Aorta

Published on: September 8, 2023

3.8K

Area of Science:

  • Cardiovascular Pathology
  • Aortic Aneurysm Research
  • Vascular Biology

Background:

  • Aortic aneurysms involve complex pathological processes.
  • Understanding the role of inflammation, vasa vasorum, and lipoprotein (a) [Lp(a)] in aneurysm wall dissection is crucial.

Purpose of the Study:

  • To investigate the relationship between inflammation, vasa vasorum, Lp(a), and aortic aneurysm wall dissection.
  • To examine the association of these factors with the development of aortic dissection.

Main Methods:

  • Morphological and morphometric analysis of aortic aneurysm wall segments (intima, media, adventitia).
  • Immunohistochemical staining using monoclonal antibodies for Lp(a), inflammatory cell markers (CD68, CD3, CD4, CD8), and vascular markers (von Willebrand factor, smooth muscle α-actin).
  • Evaluation of endothelium NO synthase expression.

Main Results:

  • Lipoprotein (a) [Lp(a)] was infrequently detected in thoracic aortic aneurysm biopsies.
  • Aortic dissection was associated with inflammatory infiltrates, medial necrosis, and neovascularization (vasa vasorum) in the aortic wall media.
  • Inflammation and new blood vessel formation in the aortic wall are key factors in dissection development.

Conclusions:

  • Inflammation and neovascularization within the aortic aneurysm wall are significantly associated with dissection.
  • Lipoprotein (a) does not appear to be a major factor in thoracic aortic aneurysms studied.
  • Targeting inflammation and vasa vasorum may be potential therapeutic strategies for preventing aortic dissection.