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Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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Related Experiment Video

Updated: Dec 6, 2025

Expansion and Enrichment of Gamma-Delta &#947;&#948; T Cells from Apheresed Human Product
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Making a case for using γδ T cells against SARS-CoV-2.

Mahboubeh Yazdanifar1, Narges Mashkour2, Alice Bertaina1

  • 1Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.

Critical Reviews in Microbiology
|October 7, 2020
PubMed
Summary
This summary is machine-generated.

Gamma delta (γδ) T lymphocytes are crucial for immune defense against respiratory viruses. This review explores their potential role in COVID-19 and strategies to enhance their antiviral function for novel therapies.

Keywords:
COVID-19SARS-CoV-2coronavirusimmune responseγδ T cell

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Area of Science:

  • Immunology
  • Virology
  • Cellular Biology

Background:

  • Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) infection and COVID-19 pathogenesis are under intensive investigation.
  • Gamma delta (γδ) T lymphocytes are key players in mucosal immunity and host defense against pathogens.
  • Previous research highlights the protective role of γδ T cells in SARS-CoV-1 infections.

Purpose of the Study:

  • To review the potential role of γδ T cells in the immune response to SARS-CoV-2.
  • To discuss insights from prior coronavirus research and recent findings.
  • To propose strategies for enhancing γδ T cell antiviral functions for COVID-19 therapeutic development.

Main Methods:

  • Literature review of existing research on γδ T cells and coronaviruses.
  • Analysis of the potential involvement of γδ T cells in COVID-19 pathogenesis.
  • Discussion of strategies to boost γδ T cell activity.

Main Results:

  • γδ T cells are strategically positioned at epithelial barriers, suggesting a role in early defense against respiratory viruses.
  • Existing data on γδ T cells in SARS-CoV-1 suggests potential relevance for SARS-CoV-2.
  • In vivo expansion of γδ T cells using bisphosphonates is a feasible approach for therapeutic research.

Conclusions:

  • γδ T cells represent a promising, yet understudied, component of the immune response to SARS-CoV-2.
  • Enhancing γδ T cell function could lead to novel therapeutic strategies for COVID-19.
  • Further research is warranted to elucidate the specific mechanisms and therapeutic potential of γδ T cells in COVID-19.