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Related Concept Videos

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When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...
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Updated: Dec 6, 2025

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When Should Asymptomatic Persons Be Tested for COVID-19?

Audrey N Schuetz1, Peera Hemarajata2, Ninad Mehta3

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Journal of Clinical Microbiology
|October 7, 2020
PubMed
Summary

The Centers for Disease Control and Prevention (CDC) initially advised against testing asymptomatic individuals for COVID-19, but later revised guidance to include testing. This editorial discusses the implications of these changes for public health.

Keywords:
COVID-19SARS-CoV-2asymptomatic testingcontact tracingsurveillance

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • The Centers for Disease Control and Prevention (CDC) issued evolving guidance on COVID-19 testing for asymptomatic individuals.
  • Initial guidance on August 24, 2020, suggested testing was unnecessary for asymptomatic contacts without high-risk conditions.
  • Revised guidance on September 19, 2020, supported testing asymptomatic individuals, including close contacts of SARS-CoV-2 positive cases.

Discussion:

  • This editorial by the American Society for Microbiology's Subcommittee on Laboratory Practices evaluates the CDC's testing recommendations.
  • It addresses the scientific rationale for testing asymptomatic individuals in the context of current knowledge of SARS-CoV-2 transmission and mitigation strategies.
  • Considerations for contact tracing and routine surveillance are discussed, emphasizing the importance of prioritizing testing.

Key Insights:

  • Asymptomatic individuals, even those with known exposure to COVID-19, present a complex challenge for testing strategies.
  • The dynamic nature of CDC guidance highlights the evolving understanding of SARS-CoV-2 epidemiology and control.
  • Prioritization of testing resources, particularly for close contacts, is crucial for effective public health interventions.

Outlook:

  • Further dialogue between public health agencies and primary stakeholders is essential for developing robust and evidence-based testing policies.
  • Continued research into the role of asymptomatic transmission is needed to refine testing and mitigation strategies.
  • The long-term impact of asymptomatic COVID-19 testing on disease surveillance and control requires ongoing evaluation.