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Cyanine conjugates in cancer theranostics
Yang Li1, Yiming Zhou1, Xiuli Yue2
1Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
Bioactive Materials
|October 7, 2020
Summary
Cyanine conjugates combine fluorescence with therapies like chemotherapy and phototherapy for cancer theranostics. This review highlights their potential for improved cancer treatment and clinical translation.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Cyanine dyes are valuable fluorophores for developing fluorescent probes.
- Cyanine's phototherapeutic potential is actively researched.
- Conjugating cyanine with therapeutic agents enhances efficacy and broadens treatment options.
Purpose of the Study:
- To review cyanine-therapeutic agent conjugates in cancer theranostics from 2014-2020.
- To explore applications in chemotherapy, phototherapy, and targeted therapy.
- To assess the clinical translation potential of these conjugates.
Main Methods:
- Literature review of scientific publications (2014-2020).
- Categorization of cyanine conjugates based on therapeutic modalities.
- Analysis of nanocarrier applications and clinical translation prospects.
Main Results:
- Cyanine conjugates are utilized in chemotherapy, phototherapy, and targeted cancer therapy.
- These conjugates can function as nanocarriers for drug delivery.
- Significant progress has been made in exploring their theranostic applications.
Conclusions:
- Cyanine-therapeutic agent conjugates show promise for advanced cancer theranostics.
- Further research into novel agents and conjugation strategies is encouraged.
- Accelerating clinical translation of these promising theranostic tools is a key goal.
