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Related Experiment Video

Updated: Dec 6, 2025

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Liver fat quantification: where do we stand?

Jitka Starekova1, Scott B Reeder2,3,4,5,6

  • 1Department of Radiology, University of Wisconsin, 600 Highland Ave, Madison, WI, 53792, USA. starekova@wisc.edu.

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Summary
This summary is machine-generated.

Nonalcoholic fatty liver disease (NAFLD) affects one billion people globally. Noninvasive imaging, particularly MRI-PDFF, offers a promising alternative to liver biopsy for diagnosing and monitoring this condition.

Keywords:
Hepatic steatosisLiver fat quantificationMagnetic resonance imagingNAFLDNASHNonalcoholic fatty liver diseaseNonalcoholic steatohepatitisNoninvasive quantitative biomarker

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Area of Science:

  • Hepatology
  • Radiology
  • Metabolic Diseases

Background:

  • Hepatic steatosis, or excessive liver fat, is a widespread condition linked to metabolic syndrome and serious health risks.
  • Nonalcoholic fatty liver disease (NAFLD) can progress to nonalcoholic steatohepatitis, leading to liver failure and cancer.
  • Liver biopsy, the current standard for NAFLD assessment, is invasive and impractical for routine use.

Purpose of the Study:

  • To review the clinical burden of nonalcoholic fatty liver disease (NAFLD).
  • To explore the role of noninvasive imaging techniques in quantifying liver fat.
  • To highlight advancements in NAFLD diagnosis and monitoring.

Main Methods:

  • Review of current literature on NAFLD and liver fat quantification.
  • Focus on noninvasive imaging modalities including MRI-PDFF, CT, and ultrasound.
  • Discussion of the clinical utility and advancements in imaging biomarkers.

Main Results:

  • Chemical-shift-encoded MRI (CSE-MRI)-based proton density fat-fraction (PDFF) shows significant promise for quantitative liver fat assessment.
  • MRI-PDFF is becoming a widely accepted imaging biomarker for NAFLD, impacting clinical practice and treatment development.
  • CT and quantitative ultrasound also offer valuable, practical advantages for detecting and monitoring hepatic steatosis.

Conclusions:

  • Noninvasive imaging methods are crucial for the diagnosis and monitoring of NAFLD, overcoming limitations of liver biopsy.
  • Quantitative imaging biomarkers like MRI-PDFF are transforming NAFLD management and therapeutic research.
  • Understanding NAFLD's burden and the role of imaging is vital for preventing severe hepatic and extrahepatic complications.