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Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned...
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In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
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When two or more objects collide with each other, they can stick together to form one single composite object (after collision). The total mass of the object after the collision is the sum of the masses of the original objects, and it moves with a velocity dictated by the conservation of momentum. Although the system's total momentum remains constant, the kinetic energy decreases, and thus such a collision is an inelastic collision. Most of the collisions between objects in daily life are...
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A servo system exemplifies a second-order system, featuring a proportional controller and load elements that ensure the output position aligns with the input position. The relationship between these components is described by a second-order differential equation. Applying the Laplace transform under zero initial conditions yields the transfer function, showing how inputs are converted to outputs in the system.
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A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
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Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...
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A Dual Task Procedure Combined with Rapid Serial Visual Presentation to Test Attentional Blink for Nontargets
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[Watch out for a second train].

Clotilde Bravetti1, Magali Le Garff-Tavernier1, Anne De Septenville1

  • 1Service d'hématologie biologique, Hôpitaux universitaires Pitié-Salpêtrière-Charles-Foix, Paris, France.

Annales De Biologie Clinique
|October 7, 2020
PubMed
Summary
This summary is machine-generated.

This case study details a patient with Waldenström macroglobulinemia who developed a distinct diffuse large B cell lymphoma (DLBCL). Advanced diagnostics confirmed separate origins for both rare blood cancers, aiding treatment strategies.

Keywords:
Waldenström macroglobulinemiaanatomopathologyclonalitycytokinesdiffuse large B cell lymphomaflow cytometry

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Waldenström macroglobulinemia (WM) is a rare lymphoplasmacytic lymphoma.
  • Diffuse large B cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
  • Co-occurrence of distinct B-cell malignancies presents diagnostic and therapeutic challenges.

Observation:

  • A patient with primary WM developed secondary DLBCL in the nasal fossae, later relapsing in the eye.
  • Multidisciplinary biological analysis, employing sensitive and specific techniques, was utilized for diagnosis.
  • The diagnostic approach aimed to differentiate the two hematological malignancies.

Findings:

  • Advanced molecular techniques revealed distinct B-cell clones for both WM and DLBCL.
  • The genetic profiles indicated independent origins for the two distinct tumor types.
  • This confirmed the non-clonal relationship between the primary and secondary malignancies.

Implications:

  • Highlights the critical role of targeted biological diagnostics in identifying rare co-existing hemopathies.
  • Demonstrates the feasibility of distinguishing independent tumor clones in complex hematological cases.
  • Enables optimized therapeutic management by clarifying the distinct nature of each malignancy.