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Updated: Dec 6, 2025

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
C(sp2)-H functionalization in non-aromatic azomethine-based heterocycles
Alexey A Akulov1, Mikhail V Varaksin2, Pieter Mampuys3
1Department of Organic & Biomolecular Chemistry, Ural Federal University, 19 Mira Str., 620002 Ekaterinburg, Russia. chupakhin@ios.uran.ru.
Abstract:
Direct C(sp2)-H functionalization of the endocyclic azomethine and aldonitrone moieties in non-aromatic azaheterocycles has established itself as a promising methodology over the last decade. Transition metal-catalyzed cross-coupling reactions, α-metalation-electrophile quenching protocols, and (metal-free) nucleophilic substitution of hydrogen reactions (SNH) are the major routes applied on cyclic imines and their derivatives. In this overview, we show the tangible progress made in this area during the period from 2008 to 2020.
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