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Related Concept Videos

Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Asepsis01:28

Asepsis

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The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
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Pneumonia I: Introduction01:30

Pneumonia I: Introduction

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Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
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Hand hygiene01:23

Hand hygiene

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
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Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Updated: Dec 6, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Sepsis Definitions in Burns.

Luis Enrique Meza-Escobar1,2, Sarah Rehou1,3, Marc G Jeschke1,2,4,5,3

  • 1Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Surgical Infections
|October 7, 2020
PubMed
Summary
This summary is machine-generated.

Sepsis definitions in burn patients are evolving. The Sepsis-3 definition is currently recommended, but research is ongoing for more specific and sensitive criteria to improve diagnosis and reduce mortality.

Keywords:
burnsdefinitionsdiagnosishistorysepsis

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Area of Science:

  • Burn Care
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Sepsis is a primary cause of mortality in burn patients.
  • The lack of a precise definition hinders early diagnosis and effective treatment.
  • Evolving definitions aim to improve patient outcomes and reduce mortality rates.

Purpose of the Study:

  • To review the historical and current definitions of sepsis in burn patients.
  • To explore novel definitions and their clinical implications.
  • To discuss the evolution and predictive value of sepsis definitions.

Main Methods:

  • Literature review of sepsis definitions in burn care.
  • Analysis of current understanding and proposed future markers.
  • Evaluation of the Sepsis-3 definition and ongoing research.

Main Results:

  • Current sepsis definitions for burns, adapted from general populations, require refinement.
  • Incorporating molecular, laboratory, and patient-specific factors is crucial for improved definitions.
  • The Sepsis-3 criteria are considered the most suitable currently, though more specific definitions are under investigation.

Conclusions:

  • Sepsis definitions in burn patients have evolved and will continue to do so.
  • The Sepsis-3 definition offers a valuable framework for critically ill burn patients.
  • Further research into more specific definitions is essential for enhancing sensitivity and specificity in diagnosing burn-related sepsis.