ORAL RUTIN SUSPENSION INTERVENE IN HEPATIC HYPERPLASIA IN RATS

Area of Science:

• Biochemistry
• Hepatology
• Pharmacology

Background:

• Rutin, a plant-derived flavonol glycoside, possesses known anti-cancer, anti-inflammatory, and anti-diabetic properties.
• Found abundantly in vegetables, rutin's therapeutic potential is under ongoing investigation.

Purpose of the Study:

• To evaluate the impact of oral rutin on liver regeneration following partial hepatectomy (PH) in Wistar rats.
• To assess rutin's effect on hepatic hyperplasia and associated biochemical markers.

Main Methods:

• Wistar rats were divided into two groups: one received rutin (40 mg/kg/day for 10 days), the other received saline.
• Both groups underwent partial hepatectomy, and hepatic hyperplasia and plasma biochemical activity were analyzed.

Main Results:

• Rutin administration significantly increased the number of mitoses at 24 and 48 hours post-PH (P=0.0022 and P=0.0152).
• Elevated AST and alkaline phosphatase serum levels were observed in the rutin group post-PH.
• Rutin treatment led to more pronounced changes in AST, mitosis, and apoptosis compared to controls.

Conclusions:

• Rutin administration positively influenced hepatic hyperplasia 24 and 48 hours after partial hepatectomy.
• The findings suggest rutin's role in promoting liver regeneration.