In Vitro Release of Curcumin and Resveratrol from Polymeric Systems: Films and Hydrogel

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Pharmacology

Background:

• Chronic wounds impede healing via inflammation, oxidative stress, and senescence.
• Natural compounds like curcumin and resveratrol, and mesenchymal stem cell (MSC) secretome, offer therapeutic potential.
• These agents possess anti-inflammatory, antioxidant, and pro-angiogenic properties beneficial for wound repair.

Purpose of the Study:

• To evaluate the release profiles of curcumin and resveratrol from two distinct polymeric platforms.
• To assess the compatibility of these compounds within wound dressing formulations.
• To determine the suitability of these platforms for sustained drug delivery in wound healing.

Main Methods:

• Two polymeric systems were investigated: poly(vinyl alcohol)/sodium alginate/carboxymethylcellulose films and an acrylate copolymer-based hydrogel with MSC secretome.
• UV-Vis spectrophotometry was employed to analyze drug release and confirm analytical selectivity.
• In vitro release kinetics of curcumin and resveratrol were monitored from both platforms.

Main Results:

• Resveratrol demonstrated consistent and progressive release from the acrylate copolymer hydrogel.
• Curcumin release was unsatisfactory in both systems, likely due to poor aqueous solubility.
• Curcumin also negatively impacted the polymer matrix integrity and reduced resveratrol release.

Conclusions:

• Resveratrol-loaded polymeric matrices are promising for sustained release in bioactive wound dressings.
• Nanoencapsulation strategies are needed to enhance curcumin's bioavailability for wound healing applications.
• Further research into formulation optimization is required for effective polyphenol delivery in wound care.