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Bioengineering lungs - current status and future prospects.

Vishal Swaminathan1, Barry R Bryant2, Vakhtang Tchantchaleishvili1

  • 1Division of Cardiac Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

Expert Opinion on Biological Therapy
|October 8, 2020
PubMed
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Developing a bioartificial lung using a patient’s own cells on a generic scaffold offers hope for end-stage pulmonary disease. Significant engineering progress has been made, but clinical application requires further research.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Pulmonary Medicine

Background:

  • End-stage pulmonary disease has limited treatment options.
  • Bioartificial lungs, using patient cells on scaffolds, represent a promising advancement.
  • Significant progress has been achieved in engineering these devices.

Purpose of the Study:

  • To review current research and progress in bioartificial lung development.
  • To identify barriers hindering the creation of successful bioartificial lungs.
  • To discuss design considerations and clinical translation challenges.

Main Methods:

  • Review of existing literature on bioartificial lung research.
  • Analysis of engineering approaches and cell-based strategies.
Keywords:
Bioartificial lungartificial lungend-stage lung diseasetissue engineering

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  • Examination of materials science and tissue engineering contributions.

    • Main Results:

    • Current bioartificial lungs demonstrate short-term gas exchange in large animals.
    • Interdisciplinary collaboration is crucial for clinical viability.
    • Optimization of design and engineering is ongoing.

    Conclusions:

    • Further research is needed to integrate cell biology, materials science, and tissue engineering.
    • Clinical translation requires overcoming significant engineering and biological hurdles.
    • Bioartificial lungs hold potential for treating end-stage pulmonary disease.