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Updated: Dec 6, 2025
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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
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A PATIENT WITH AN ATYPIC NECK MASS LESION
F N Korkmaz1,2, A Gokcay Canpolat3, B Bilezikci4
1Ankara University, Faculty of Medicine - Department of Endocrinology and Metabolism, Ankara, Turkey.
Acta Endocrinologica (Bucharest, Romania : 2005)
|October 8, 2020
Summary
An 81-year-old woman experienced a hypertensive crisis during surgery for a neck mass, revealing a rare combination of paraganglioma and medullary thyroid carcinoma linked to an SDHD gene mutation.
Area of Science:
- Endocrinology
- Oncology
- Genetics
Background:
- Presents a case of an 81-year-old woman with essential hypertension and an incidentally discovered neck mass.
- The mass was initially suspected to be parathyroid adenoma or lymphadenopathy.
Observation:
- During surgery for multinodular goiter and the neck mass, the patient experienced a significant intraoperative hypertensive crisis.
- Post-operative pathology revealed a 2 mm medullary thyroid carcinoma with C-cell hyperplasia and a cervical paraganglioma.
Findings:
- The patient was diagnosed with concomitant medullary thyroid carcinoma and paraganglioma.
- Genetic counseling and molecular testing identified a disease-causing mutation in the succinate dehydrogenase gene D (SDHD).
Implications:
- This case highlights the importance of considering rare genetic syndromes in patients with combined endocrine tumors.
- Highlights the diagnostic challenge and management of patients with paraganglioma and medullary thyroid carcinoma.
- Underscores the clinical significance of intraoperative hypertensive events as potential indicators of underlying neuroendocrine tumors.
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