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High JAK2 Protein Expression Predicts a Poor Prognosis in Patients with Resectable Pancreatic Ductal Adenocarcinoma
Yang Song1, Mei-Yue Tang1, Wei Chen1
1Department of Oncology, Shengjing Hospital of China Medical University, 36 Sanhao Road, Shenyang 110004, China.
Background:
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies worldwide. The JAK/STAT signaling pathway is involved in pancreatic cancer tumorigenesis. However, the prognostic value of JAK2 expression in resectable PDAC is unclear.
Method:
In this study, we performed a clinicopathological analysis of 62 resectable PDAC cases with a primary focus on survival. JAK2 expression was examined by immunohistochemistry. The relationship between JAK2 expression and clinicopathological features and prognosis was analyzed.
Results:
Survival curve analyses revealed that high levels of JAK2 expression predict a poor prognosis in resectable PDAC patients. Multivariate analysis confirmed that JAK2 expression can predict the prognosis of PDAC.
Conclusions:
Assessment of JAK2 protein expression may be a promising method to predict prognosis in patients with resectable PDAC.
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