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Published on: April 18, 2025
Echocardiographic features of patients with COVID-19 infection: a cross-sectional study
Hasan Ali Barman1,2, Adem Atici3, Esra Aktas Tekin4
1Institute of Cardiology, Department of Cardiology, Istanbul University, Cerrahpasa, Istanbul, Turkey. drhasanali@hotmail.com.
Insights
Severe COVID-19 patients show impaired cardiac function, with larger ventricles and reduced ejection fraction compared to non-severe cases. Echocardiography reveals significant differences in cardiac dimensions and function between severe and non-severe COVID-19 patients.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Imaging
Background:
- COVID-19 can lead to cardiac involvement, significantly increasing mortality rates.
- Understanding echocardiographic differences in COVID-19 patients is crucial for prognosis.
- Cardiac dysfunction is a key factor in the high mortality observed in severe COVID-19.
Purpose of the Study:
- To investigate and compare echocardiographic features between severe and non-severe COVID-19 patient groups.
- To identify echocardiographic parameters indicative of disease severity and prognosis in COVID-19 patients.
Main Methods:
- Single-center study analyzing data from 90 hospitalized COVID-19 patients.
- Two-dimensional echocardiography (2DE) performed on all patients.
- Comparison of right ventricular (RV) and left ventricular (LV) function parameters between severe and non-severe groups.
Main Results:
- Severe COVID-19 patients exhibited larger RV and LV diameters, lower left ventricular ejection fraction (LVEF), and reduced RV fractional area change (RV-FAC).
- Pericardial effusions were more frequent in the severe group (23% vs. 0%).
- LVEF, right atrial diameter, high-sensitivity troponin I, d-dimer, and systolic pulmonary artery pressure were independent predictors of RV dilatation.
Conclusions:
- COVID-19 infection, particularly in severe cases, leads to decreased right and left ventricular function.
- Two-dimensional echocardiography (2DE) is a valuable bedside tool for assessing the clinical status and prognosis of COVID-19 patients.
- Echocardiographic findings can help stratify risk and guide management in COVID-19 patients with cardiac involvement.
Abstract:
COVID-19 patients with cardiac involvement have a high mortality rate. The aim of this study was to investigate the echocardiographic features in COVID-19 patients between severe and non-severe groups. For this single-center study, data from patients who were treated for COVID-19 between March 25, 2020 and April 15, 2020 were collected. Two-dimensional echocardiography (2DE) images were obtained for all patients. Patients were divided into two groups based on the severity of their COVID-19 infections. 2DE parameters indicating right ventricular (RV) and left ventricular (LV) functions were compared between the two groups. A total of 90 patients hospitalized for COVID-19 were included in this study. The mean age of the severe group (n = 44) was 63.3 ± 15.7 years, and 54% were male. The mean age of non-severe group (n = 46) was 49.7 ± 21.4 years, and 47% were male. In the severe group, RV and LV diameters were larger (RV, 36.6 ± 5.9 mm vs. 33.1 ± 4.8 mm, p = 0.003; LV 47.3 ± 5.8 mm vs. 44.9 ± 3.8 mm, p = 0.023), the LE ejection fraction (LVEF) and the RV fractional area change (RV-FAC) were lower (LVEF, 54.0 ± 9.8% vs. 61.9 ± 4.8%, p < 0.001; RV-FAC, 41.4 ± 4.1% vs. 45.5 ± 4.5%, p < 0.001), and pericardial effusions were more frequent (23% vs. 0%) compared to patients in the non-severe group. A multiple linear regression analysis determined that LVEF, right atrial diameter, high-sensitivity troponin I, d-dimer, and systolic pulmonary artery pressure, were independent predictors of RV dilatation. The results demonstrate that both right and left ventricular functions decreased due to COVID-19 infection in the severe group. 2DE is a valuable bedside tool and may yield valuable information about the clinical status of patients and their prognoses.
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