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Updated: Dec 6, 2025

Enrichment of Detergent-insoluble Protein Aggregates from Human Postmortem Brain

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Published on: October 24, 2017

Differences Between Central and Peripheral Postmortem Tryptase Levels.

Jack Garland¹, Benjamin Ondruschka², Ugo Da Broi³

¹From the Forensic and Analytical Science Service, NSW Health Pathology, New South Wales, Australia.

The American Journal of Forensic Medicine and Pathology

|October 8, 2020

Summary

This summary is machine-generated.

Postmortem tryptase testing for fatal anaphylaxis diagnosis is recommended from femoral veins. This study found no significant differences between femoral and central blood, but noted concerning outliers in central samples.

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Area of Science:

Forensic pathology
Biochemistry
Toxicology

Background:

Postmortem tryptase is crucial for diagnosing fatal anaphylaxis.
Current recommendations favor peripheral (femoral) vein sampling due to potential central blood elevation.
Sampling methods can influence postmortem tryptase levels.

Purpose of the Study:

To compare postmortem tryptase levels in femoral, central venous, and arterial blood.
To validate current recommendations for femoral vein sampling.

Main Methods:

Aspirated femoral vein blood (recommended method) and central blood (inferior vena cava, aorta) from 50 nonanaphylactic deaths.
Pairwise comparison of tryptase levels between sampling sites.

Main Results:

No statistically significant differences were found in postmortem tryptase between central and femoral vein blood.
Sporadic outliers with high tryptase levels were observed in central blood, particularly aortic samples.

Conclusions:

Femoral vein blood remains the preferred sample for postmortem tryptase analysis.
Existing recommendations for femoral vein sampling are supported, despite central blood outliers.