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Updated: Dec 6, 2025

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Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry
Published on: November 14, 2025
138
A bimolecular i-motif mediated FRET strategy for imaging protein homodimerization on a living tumor cell surface
Ailing Kan1, Xiaoting Liu, Xiaowen Xu
1School of Chemistry and Chemical Engineering, Shandong University, 250100 Jinan, P. R. China. wjiang@sdu.edu.cn.
Abstract:
A bimolecular i-motif mediated FRET strategy was developed based on the proximity-induced folding of two identical cytosine-rich DNA strands. This strategy affords a FRET signal that is highly matched to the dimerization event, and enabled accurate and dynamic in situ imaging of Met homodimerization on a living tumor cell surface.

