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Evoked potentials reveal neural circuits engaged by human deep brain stimulation
Stephen L Schmidt1, David T Brocker1, Brandon D Swan1
1Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Brain Stimulation
|October 9, 2020
Summary
Deep brain stimulation (DBS) for Parkinson's disease reveals linked neural dynamics. DBS evoked potentials show interconnected STN and GP circuits, offering a biomarker for adaptive DBS.
Area of Science:
- Neuroscience
- Biomedical Engineering
Background:
- Deep brain stimulation (DBS) effectively treats Parkinson's disease motor symptoms.
- Mechanisms of DBS action and neural correlates of Parkinson's symptoms are not fully understood.
Purpose of the Study:
- Investigate neural responses to DBS to map circuit connectivity.
- Identify neuronal interactions as potential mechanisms underlying DBS efficacy.
Main Methods:
- Recorded neural activity evoked by subthalamic nucleus (STN) DBS in Parkinson's patients.
- Simultaneously recorded activity in contralateral STN and ipsilateral globus pallidus (GP) segments (GPi, GPe).
Main Results:
- DBS local evoked potentials (DLEPs) were consistent across subjects.
- A biophysical model confirmed DLEPs originate from reciprocal STN-GPe connections.
- DLEPs showed frequency/duration dependency, correlated with beta oscillations, and appeared as a 350 Hz high-frequency oscillation (HFO).
Conclusions:
- DBS evoked potentials indicate highly interlinked STN and GP intrinsic dynamics.
- These findings suggest a potential new biomarker for adaptive DBS systems.
