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Inflammatory Responses in Oro-Maxillofacial Region Expanded Using Anisotropic Hydrogel Tissue Expander
Kholoud Mohamed Ali Salim1, Aminah Abd Jalil2, Zamri Radzi3
1Department of Oro-Maxillofacial Surgical & Medical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur 50603, Malaysia.
Materials (Basel, Switzerland)
|October 10, 2020
Summary
Anisotropic hydrogel tissue expanders show promise for tissue reconstruction. Expanded tissues exhibited no inflammatory response, though interleukin-1 alpha was detected, warranting further study.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Reconstruction of oral and facial defects often requires soft tissue replacement.
- Tissue expanders are used to generate supplementary tissue under controlled force.
- Investigating inflammatory responses to novel tissue expanders is crucial for clinical application.
Purpose of the Study:
- To investigate the inflammatory responses associated with anisotropic hydrogel tissue expanders.
- To evaluate the suitability of these expanders for tissue reconstruction.
Main Methods:
- Anisotropic hydrogel tissue expanders were implanted in Sprague Dawley rats (n=4).
- Control group (n=3) did not receive expanders.
- Histological analysis and immunohistochemistry for IL-1α, IL-6, and TNF-α were performed on harvested skin samples.
Main Results:
- Interleukin-1 alpha (IL-1α) expression was observed in expanded tissues, but not in controls.
- No significant difference in IL-6 and TNF-α levels between groups.
- Histological analysis revealed no inflammatory response in expanded tissues.
Conclusions:
- Anisotropic hydrogel tissue expanders may be suitable for tissue replacement and engraftment.
- Expanded tissues did not show signs of inflammation.
- The role of IL-1α in expanded tissues without visible inflammation requires further investigation.
