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Updated: Dec 6, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Patient Selection for Protected Percutaneous Coronary Intervention: Who Benefits the Most?
Seung-Hyun Kim1, Stefan Baumann1, Michael Behnes1
1First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Center for AngioScience (ECAS), and DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg/Mannheim, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany.
Insights
Protected percutaneous coronary intervention (PCI) uses mechanical support for complex cases. This review guides patient selection for protected PCI, improving safety in high-risk individuals with comorbidities.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Devices
Background:
- Percutaneous coronary intervention (PCI) has advanced for complex lesions.
- Increasing comorbidities in patients challenge physiologic tolerance for PCI.
- Hemodynamic instability during PCI necessitates strategies for safe revascularization.
Purpose of the Study:
- To review patient selection criteria for protected PCI.
- To assess the utility of mechanical circulatory support in high-risk PCI patients.
- To provide practical approaches for implementing protected PCI.
Main Methods:
- Literature review of clinical data on protected PCI.
- Analysis of patient characteristics and outcomes.
- Evaluation of mechanical circulatory support devices in complex PCI.
Main Results:
- Protected PCI demonstrates potential for safe complete revascularization in select high-risk patients.
- Mechanical circulatory support can mitigate hemodynamic instability during complex PCI.
- Current data is still debated regarding optimal patient selection for protected PCI.
Conclusions:
- Protected PCI is a viable option for high-risk patients undergoing complex PCI.
- Careful patient selection is crucial for maximizing the benefits of protected PCI.
- Further research is needed to refine guidelines for protected PCI utilization.
Abstract:
The evolution of percutaneous coronary intervention (PCI) enables a complete revascularization of complex coronary lesions. However, simultaneously, patients are presenting nowadays with higher rates of comorbidities, which may lead to a lower physiologic tolerance for complex PCI. To avoid hemodynamic instability during PCI and achieve safe complete revascularization, protected PCI using mechanical circulatory support devices has been developed. However, which patients would benefit from the protected PCI is still in debate. Hence, this review provides practical approaches for the selection of patients by outlining current clinical data assessing utility of protected PCI in high-risk patients.
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