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Updated: Dec 6, 2025
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Allergic contact dermatitis to cosmetics: retrospective analysis of a population subjected to patch tests between
Mariana de Figueiredo Silva Hafner1, Ana Carolina Rodrigues2, Rosana Lazzarini1
1Dermatology Clinic, Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
Background:
Cosmetics are part of the daily life of the population, and their use can lead to allergic contact dermatitis.
Objectives:
To assess the profile of patients diagnosed with allergic contact dermatitis to cosmetics treated at a referral center for 13 years, as well as the characteristics of the clinical picture and allergens involved.
Methods:
This was a retrospective study, with analysis of medical records of patients attended at this service. The individuals included had a diagnostic hypothesis of allergic contact dermatitis to cosmetics and had previously been submitted to epicutaneous tests.
Results:
A total of 1405 medical records were analyzed, 403 (28.7%) with suspected allergic contact dermatitis to cosmetics and 232 (16.5%) with confirmed diagnosis. Of these, 208 (89.7%) were women, and the age group most affected was 31 - 60 years. The most common locations were face in 195 cases (25.8%), cervical region in 116 (15.3%), and trunk in 96 (12.6%). The main allergens in the contact tests were toluene-sulfonamide-formaldehyde resin in 69 cases (29.7%), paraphenylenediamine in 54 (26.3%), Kathon CG® in 41 (20.7%), and fragrance-mix 1 in 29 (16.4%). In 154 (66.4%) of the 232 patients with a confirmed diagnosis of allergic contact dermatitis to cosmetics it was possible to specify the cosmetic product responsible for the lesions.
Study Limitations:
The absence of some allergens considered important in the world as causes of allergic contact dermatitis, which are not readily accessible among us.
Conclusions:
The data of the analyzed population (predominance of young women), as well as the location of the lesions (face and cervical area) and the main allergens involved were consistent with those from the world literature.
