Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures

Area of Science:

• Lipidomics
• Mass Spectrometry
• Biochemistry

Background:

• Standardized reporting of lipid structures is crucial for lipidomics data management.
• Existing classification systems require updates to accommodate new lipid discoveries.

Purpose of the Study:

• To present an updated LIPID MAPS classification system and shorthand notation for lipids.
• To facilitate standardized reporting of lipidomics data.
• To expand the scope of lipid nomenclature.

Main Methods:

• Updating the LIPID MAPS classification system.
• Developing an enhanced shorthand notation for lipid structures.
• Incorporating annotations for ring double bond equivalents, oxygen atoms, and atom labeling.

Main Results:

• An updated classification and shorthand notation for Fatty Acyls, Glycerolipids, Glycerophospholipids, Sphingolipids, and Sterols.
• The notation accommodates newly delineated oxygenated lipid species.
• Expanded notation covers lipids from plant and yeast, not just mammalian phyla.
• Inclusion of atom annotation for stable isotope-labeled compounds.

Conclusions:

• The updated lipid classification and shorthand notation provide a standard for lipid data presentation.
• This system enhances the communication and storage of lipidomics data.
• The standardized system supports diverse mass spectrometric analyses and applications.