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[Origin and evolution of peptide-protein bioregulators]
Zhurnal Evoliutsionnoi Biokhimii I Fiziologii
|May 1, 1987
Summary
Cellular regulatory systems likely evolved early, with peptide bioregulators emerging in prokaryotes. Similar molecular fragments from limited proteolysis may mediate diverse signaling pathways, impacting growth factors and hormones.
Area of Science:
- Evolutionary biology
- Molecular biology
- Biochemistry
Context:
- Cellular regulatory systems and their evolutionary origins.
- Early biochemical systems in prokaryotic cells.
- Role of peptide and protein bioregulators in evolution.
Purpose:
- To discuss possible evolutionary pathways of cellular regulatory systems.
- To compare primary autocrine bioregulators with growth factors.
- To propose models for cellular bioregulation involving prehormones and proteolysis.
Summary:
- Peptide and protein bioregulators likely emerged early in prokaryotic evolution, linked to protein synthesis and endocytosis.
- Cell receptors and peptide/protein ligands (e.g., immunoglobulins) may act as prehormones, yielding low-molecular peptides (tetines) via proteolysis.
- Identical or similar peptide fragments, generated by limited proteolysis, may mediate the effects of diverse signaling molecules like growth factors, hormones, and immunoglobulins, based on biochemical universality.
Impact:
- Suggests a unified mechanism for diverse cellular signaling pathways.
- Provides insights into the evolutionary origins of complex regulatory systems.
- Highlights the potential role of limited proteolysis in generating signaling peptides.