Relationship between bone turnover markers and oxidative stress in children with type 1 diabetes mellitus
Doaa El Amrousy1, Dalia El-Afify2, Ahmed Shabana3
1Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt. doaamoha@yahoo.com.
Insights
Oxidative stress is linked to altered bone turnover in children with type 1 diabetes mellitus (T1DM). Lower bone formation and higher bone breakdown markers were observed in T1DM patients, correlating with oxidative stress indicators.
Area of Science:
- Pediatric Endocrinology
- Bone Metabolism
- Oxidative Stress Research
Background:
- Oxidative stress may negatively impact bone health in children with type 1 diabetes mellitus (T1DM).
- The specific relationship between oxidative stress and bone turnover in pediatric T1DM remains understudied.
Purpose of the Study:
- To investigate the association between oxidative stress markers and bone turnover markers in children with T1DM.
- To determine if oxidative stress influences bone metabolism in pediatric patients with T1DM.
Main Methods:
- Compared 40 children with T1DM to 40 healthy controls matched for age and sex.
- Measured plasma bone turnover markers (alkaline phosphatase, procollagen type-1 amino-terminal propeptide [P1NP], urinary deoxypyridinoline [DPD]) and oxidative stress markers (glutathione, superoxide dismutase [SOD], malondialdehyde [MDA]).
Main Results:
- Children with T1DM exhibited lower P1NP and higher DPD levels, indicating altered bone turnover.
- T1DM patients showed reduced glutathione and SOD, and elevated MDA, signifying increased oxidative stress.
- Significant correlations were found between bone turnover markers and oxidative stress markers, with glutathione and MDA predicting P1NP and DPD levels.
Conclusions:
- An association exists between oxidative stress and bone turnover markers in children with T1DM.
- Increased oxidative stress may impair bone turnover in pediatric T1DM, suggesting therapeutic strategies targeting glycemic control and oxidative stress reduction could benefit bone health.
Background:
Oxidative stress in children with type 1 DM (T1DM) may negatively affect the bone.
Methods:
This study included 40 children with T1DM as the patient group and 40 healthy children of matched age and sex as the control group. Plasma alkaline phosphatase, procollagen type-1 amino-terminal propeptide (P1NP), and urinary deoxypyridinoline (DPD) were measured to assess bone turnover. Glutathione, superoxide dismutase (SOD), and malondialdehyde (MDA) were measured to assess oxidative stress.
Results:
Patients with T1DM had a significantly lower P1NP level but a significantly higher urinary DPD level compared to the control group. Moreover, there were significantly lower glutathione and SOD levels with significantly higher MDA levels in patients with T1DM. We found a significant positive correlation between P1NP level and both glutathione and SOD levels but a significant negative correlation between P1NP and MDA in patients with T1DM. There was a significant negative correlation between DPD levels and both glutathione and SOD levels and a significant positive correlation between DPD and MDA. Moreover, glutathione was a significant predictor for both P1NP and DPD levels, while MDA was a significant predictor for P1NP levels.
Conclusions:
There is an association between oxidative stress and bone turnover markers in children with T1DM.
Impact:
Oxidative stress can negatively affect bone but the exact relationship between oxidative stress and bone turnover in T1DM has not been previously studied in pediatrics. For the best of our knowledge, our study was the first to assess the relationship between oxidative stress and bone turnover in children with T1DM. We revealed that increased oxidative stress in children and adolescents with T1DM may be involved in the impairment of bone turnover process, so treatment strategies toward better glycemic control and decreasing oxidative stress may be beneficial in preventing and treating diabetic bone disease in these children.
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