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Inactivation of Epigenetic Regulators due to Mutations in Solid Tumors
M V Nemtsova1,2, D S Mikhaylenko3,2, E B Kuznetsova1
1Institute of Molecular Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russia.
Biochemistry. Biokhimiia
|October 12, 2020
Summary
Mutations in epigenetic regulators drive cancer development. This review details genetic changes in these regulators, their cellular impacts, and clinical relevance for cancer diagnostics and treatment.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Carcinogenesis involves somatic mutations in oncogenes and tumor suppressor genes.
- Epigenetic alterations, including DNA methylation and histone modifications, are crucial in neoplasm development.
- Mutations in genes encoding epigenetic regulators are of significant interest.
Purpose of the Study:
- To review germline and somatic mutations in key epigenetic regulators.
- To emphasize somatic mutations in solid human tumors.
- To discuss functional consequences, clinical associations, and therapeutic strategies.
Main Methods:
- Review of literature on genetic mutations in epigenetic regulators.
- Analysis of functional consequences at the cellular level.
- Examination of clinical associations and diagnostic applications.
Main Results:
- Detailed description of germline and somatic mutations in epigenetic regulators.
- Emphasis on the role of somatic mutations in solid tumors.
- Presentation of functional and clinical implications of these mutations.
Conclusions:
- Mutations in epigenetic regulators significantly contribute to human cancer.
- Understanding these mutations is vital for cancer diagnostics and targeted therapies.
- Further research into epigenetic mechanisms can lead to novel treatment strategies.
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