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[Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein of Nervous System Signaling Pathways].
V E Baksheeva1, A A Zamyatnin1,2,3,4, E Yu Zernii1,5
1Belozersky Institute of Physicochemical Biology, Moscow State University, Moscow, 119992 Russia.
Molekuliarnaia Biologiia
|December 8, 2023
Summary
Neuronal calcium sensor-1 (NCS-1) regulates nervous system functions. Aberrant NCS-1 activity, influenced by zinc and oxidative stress, contributes to neurodegenerative diseases.
Area of Science:
- Neuroscience
- Molecular Biology
- Cell Signaling
Context:
- Intracellular calcium signaling is crucial for nervous system functions, including neuronal excitability and plasticity.
- Neuronal calcium sensor-1 (NCS-1) is a key protein translating calcium signals into cellular responses within the central nervous system (CNS).
Purpose:
- To review the localization, expression, structure, and molecular properties of NCS-1.
- To examine the signaling activity of NCS-1 in health and disease, focusing on zinc-dependent redox regulation.
Summary:
- NCS-1 regulates vital neuronal processes like growth, survival, neurotransmission, and synaptic plasticity.
- Mobile zinc and oxidative stress can induce NCS-1 oxidation, forming a disulfide dimer (dNCS-1) with altered functions.
- Aberrant NCS-1 activity, driven by zinc and redox changes, can promote neuronal survival or apoptosis, potentially leading to neurodegeneration.
Impact:
- Understanding NCS-1's role in neurodegeneration may reveal therapeutic targets.
- Elucidates the molecular mechanisms linking cellular signaling, oxidative stress, and neurological disorders.
- Provides insights into the complex interplay between calcium, zinc, and redox balance in neuronal health.
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