Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

994
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
994
Causality in Epidemiology01:21

Causality in Epidemiology

1.3K
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
1.3K
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

1.6K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.6K
Types of Toxins01:36

Types of Toxins

3.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.0K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

1.9K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial Intelligence in and Beyond Healthcare Psychology.

Journal of clinical psychology in medical settings·2025
Same author

Transforming Alzheimer's Digital Caregiving through Large Language Models.

Current Alzheimer research·2024
Same author

Post-Traumatic Headache is Associated with Worse Anxiety and Mood Symptoms in Adolescent Mild Traumatic Brain Injury.

Neurology and neurobiology (Tallinn, Estonia)·2024
Same author

Computerized Cognitive Function Does Not Correlate With Choice Reaction Time During a Hopping Task.

Journal of sport rehabilitation·2023
Same author

Single low-dose targeted bevacizumab infusion in adult patients with steroid-refractory radiation necrosis of the brain: a phase II open-label prospective clinical trial.

Journal of neurosurgery·2022
Same author

Mechanism of olfactory deficit in neurotrauma and its related affective distress: A narrative review.

World journal of psychiatry·2022
Same journal

Sports Neurology.

Neurologic clinics·2026
Same journal

Sports-Related Peripheral Nerve Injuries.

Neurologic clinics·2026
Same journal

Active Rehabilitation and Return to Play in Sports-Related Concussion.

Neurologic clinics·2026
Same journal

Autonomic Assessment and Management in Sports-Related Concussion.

Neurologic clinics·2026
Same journal

Management of Vestibular Symptoms in Sports-Related Concussion.

Neurologic clinics·2026
Same journal

Neuropsychological Assessment in Sport-Related Concussion: Evidence, Controversies, and Clinical Applications.

Neurologic clinics·2026
See all related articles

Related Experiment Video

Updated: Dec 6, 2025

Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons
15:05

Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons

Published on: February 5, 2015

9.6K

Neurotoxicology: Clinical Approach and Causal Inference.

Mam Ibraheem1, Dong Y Han2, Michael R Dobbs3

  • 1Department of Neurology, University of Kentucky, 740 South Limestone, KY Clinic, J401, Lexington, KY 40536, USA; US Department of Veterans Affairs, Lexington VA Medical Center, Troy Bowling Campus, 1101 Veterans Drive, Room A303a, Mail Code: 127-CD, Lexington, KY 40502, USA.

Neurologic Clinics
|October 12, 2020
PubMed
Summary
This summary is machine-generated.

Clinical neurotoxicology is an emerging neurologic subspecialty. This article offers a foundational approach to assessing neurotoxic exposures and injuries, bridging a critical knowledge gap for clinicians.

Keywords:
CausalityEpidemiologyEvidence-based toxicologyNeurologyToxicology

More Related Videos

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line
08:23

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Published on: August 9, 2014

11.7K
Viability Assays for Cells in Culture
12:03

Viability Assays for Cells in Culture

Published on: January 20, 2014

47.0K

Related Experiment Videos

Last Updated: Dec 6, 2025

Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons
15:05

Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons

Published on: February 5, 2015

9.6K
Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line
08:23

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Published on: August 9, 2014

11.7K
Viability Assays for Cells in Culture
12:03

Viability Assays for Cells in Culture

Published on: January 20, 2014

47.0K

Area of Science:

  • Neurology
  • Toxicology
  • Environmental Health

Background:

  • Clinical neurotoxicology remains an underrecognized subspecialty within neurology.
  • Neurology residency programs rarely provide structured education or training in neurotoxicology.
  • Neurotoxic exposures and resultant neurological injuries are prevalent in the general population.

Purpose of the Study:

  • To establish a basic framework for the clinical assessment of neurotoxic exposures.
  • To guide causal inference in cases of suspected neurotoxic injury.
  • To address the existing knowledge deficit in clinical neurotoxicology practice.

Main Methods:

  • Review of existing literature on clinical neurotoxicology assessment.
  • Development of a systematic approach for patient evaluation.
  • Identification of key principles for establishing a link between exposure and neurological outcome.

Main Results:

  • A structured approach to clinical neurotoxicology assessment is presented.
  • Methodologies for inferring causality in neurotoxicology are outlined.
  • Strategies for integrating interdisciplinary resources are proposed.

Conclusions:

  • Clinical neurotoxicology requires greater recognition and integration into neurological training.
  • A systematic approach can improve the diagnosis and management of neurotoxic injuries.
  • Interdisciplinary collaboration is essential for advancing the field of clinical neurotoxicology.