Pharmacogenetics in Psychiatry: An Update on Clinical Usability
Ron H N van Schaik1, Daniel J Müller2,3, Alessandro Serretti4
1Department of Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Abstract:
Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake, although still leads to discussions as to its clinical use. Psychiatry constitutes a field where pharmacogenomic testing might help in guiding drug therapy. To address current challenges, this minireview provides an update regarding genotyping (SNP analysis/arrays/NGS), structural variant detection (star-alleles/CNVs/hybrid alleles), genotype-to-phenotype translations, cost-effectiveness, and actionability of results (FDA/CPIC/PharmGKB) regarding clinical importance of pre-emptive pharmacogenomic testing for prescription of antidepressants and antipsychotics.
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