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Demographics, laboratory parameters and outcomes of 1061 patients with coronavirus disease 2019: a report from
M Pourabdollah Toutkaboni1, E Askari1, N Khalili2,3
1Chronic Respiratory Diseases Research Centre, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insights
This study analyzed COVID-19 patient characteristics in Iran, finding older age and specific laboratory markers like D-dimer correlate with mortality. These findings aid in managing coronavirus disease 2019 (COVID-19) patients.
Area of Science:
- Infectious Diseases
- Epidemiology
- Clinical Medicine
Background:
- Coronavirus disease 2019 (COVID-19) emerged globally, necessitating characterization within diverse populations.
- Understanding the demographics, clinical presentation, and outcomes of COVID-19 patients in Iran is crucial for effective healthcare management.
Purpose of the Study:
- To determine the demographic, laboratory, and outcome characteristics of COVID-19 patients in Iran.
- To identify factors associated with mortality in hospitalized COVID-19 patients.
Main Methods:
- Retrospective analysis of 1061 patients admitted to Masih Daneshvari Hospital, Tehran, Iran, from February 20 to April 2, 2020.
- Collection and analysis of demographic data, laboratory findings (including lymphocyte counts), and patient outcomes (hospitalization, ICU admission, mortality).
- Statistical analysis to compare characteristics between non-survivors and survivors, and to correlate laboratory markers with mortality.
Main Results:
- The study included 1061 patients; 65.2% were male, with a median age of 55 years. Overall mortality was 12.2%.
- Patients who died were significantly older than those hospitalized in the ward (p < 0.001). Lymphopenia was observed in 66.7% of patients.
- D-dimer, serum ferritin, and albumin showed the strongest correlations with mortality (r = 0.455, r = 0.412, r = -0.406, respectively; p < 0.001 for each).
Conclusions:
- Demographic and clinical characteristics of Iranian COVID-19 patients were elucidated.
- Laboratory markers, particularly D-dimer, serum ferritin, and albumin levels, are significant predictors of mortality in COVID-19 patients.
- These laboratory findings can inform clinical management strategies for individuals diagnosed with COVID-19.
Abstract:
We aimed to determine the characteristics of coronavirus disease 2019 (COVID-2019) among the Iranian population. In this study, we collected and analysed the demographics, laboratory findings and outcomes of patients with COVID-19 who were admitted to Masih Daneshvari Hospital in Tehran, Iran between 20 February 2020 and 2 April 2020. Among 1061 patients, 692 (65.2%) were male and the median age was 55 years (interquartile range (IQR), 44-66 years). Totally, 129 (12.2%) patients died during hospitalization in the ward or intensive care unit. From the remaining 932 individuals, 46 (5.0%) were admitted to the intensive care unit and 886 (95.0%) were hospitalized in the ward. Those patients who died were significantly older than those hospitalized in the ward (p < 0.001). The median absolute number of lymphocytes was 1.2 × 103/μL (IQR 0.9 × 103 to 1.6 × 103/μL) and 708 (66.7%) patients had lymphopenia (absolute lymphocyte count <1500/μL). Among the laboratory tests, D-dimer, serum ferritin and albumin had the strongest correlations with mortality (r = 0.455, r = 0.412, r = -0.406, respectively; p < 0.001 for each one). In conclusion, laboratory findings could provide useful information with regard to the management of individuals with COVID-19.
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