Related Experiment Video
Updated: Dec 6, 2025
07:09
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
2.2K
Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives.
Sebastian Rosch1, Karl-Philipp Rommel1, Markus Scholz2,3
1Department of Cardiology, Heart Center Leipzig at University of Leipzig Leipzig, Germany.
Cardiac Failure Review
|October 12, 2020
Summary
Heart failure with preserved ejection fraction (HFpEF) lacks effective treatments due to complex causes. Transcriptomic biomarker research offers new hope for diagnosis, prognosis, and personalized therapies for HFpEF patients.
Area of Science:
- Cardiology
- Genomics
- Biomarker Research
Background:
- Heart failure with preserved ejection fraction (HFpEF) is rising and more common than heart failure with reduced ejection fraction.
- HFpEF presents complex pathophysiology and clinical diversity, hindering effective treatment development.
- Current treatment options for HFpEF remain limited.
Purpose of the Study:
- To review transcriptomic biomarker research in HFpEF.
- To explore future perspectives for transcriptomic biomarkers in HFpEF.
- To highlight the potential of molecular insights for improving HFpEF management.
Main Methods:
- Review of existing literature on transcriptomic biomarkers in HFpEF.
- Analysis of the potential of detailed phenotyping and molecular pathomechanisms.
- Discussion of study design requirements for advancing HFpEF research.
Main Results:
- Transcriptomic biomarker research is a promising avenue for HFpEF.
- Detailed characterization of HFpEF phenotype and molecular mechanisms is crucial.
- Large-scale, well-designed studies are necessary to validate findings.
Conclusions:
- Transcriptomic biomarkers may enable earlier diagnosis and better prognostication of HFpEF.
- Understanding molecular pathways can identify novel therapeutic targets for HFpEF.
- Tailored therapies based on patient heterogeneity could improve HFpEF outcomes and quality of life.
Related Concept Videos
01:29Heart Failure II: Pathophysiology
502
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
502
01:17Pathophysiology of Heart Failure
2.4K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.4K
01:27Heart Failure I: Introduction
547
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
547
01:30Heart Failure V: Medical Management
122
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
122
01:30Heart Failure IV: Classification and Diagnostic Evaluation
183
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
183
01:26Heart Failure III: Clinical Manifestations
332
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
332