Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

3.3K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.3K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.9K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.9K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.6K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.6K
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

2.0K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.0K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.9K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

3.3K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical phenotypes in α<sub>1</sub>-antitrypsin deficiency: a cluster analysis on EARCO data.

ERJ open research·2026
Same author

The epidemiological burden and societal cost of 14 respiratory conditions in the World Health Organization European region: systematic evidence map and economic analysis.

ERJ open research·2026
Same author

A Real-World Evaluation of Therapeutic Inertia in Patients with Severe Uncontrolled Chronic Obstructive Pulmonary Disease.

International journal of chronic obstructive pulmonary disease·2026
Same author

Lobar Lung Density Embeddings with a Transformer encoder (LobTe) to predict emphysema progression in COPD.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention·2026
Same author

Temperature exposure and time adolescents spend in physical activity across intensity levels.

Environmental epidemiology (Philadelphia, Pa.)·2026
Same author

Development of an artificial intelligence prediction model for moderate-to-severe COPD exacerbations using continuous multiple unobtrusive sensors: protocol of a multicentre prospective observational study.

BMJ open respiratory research·2026

Related Experiment Video

Updated: Dec 6, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.3K

Phenotypic characterisation of early COPD: a prospective case-control study.

Borja G Cosío1,2, Sergi Pascual-Guardia2,3,4, Alicia Borras-Santos2,5

  • 1Servicio de Neumología, Hospital Universitario Son Espases-IdISBa, Palma de Mallorca, Spain.

ERJ Open Research
|October 12, 2020
PubMed
Summary

Early chronic obstructive pulmonary disease (COPD) presents with significant symptoms and lung abnormalities, often undiagnosed. Family history and early-life respiratory issues may indicate an early-life origin for this condition.

More Related Videos

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
07:10

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

10.1K
Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

1.1K

Related Experiment Videos

Last Updated: Dec 6, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.3K
Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
07:10

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

10.1K
Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

1.1K

Area of Science:

  • Pulmonology
  • Respiratory Medicine
  • Epidemiology

Background:

  • Phenotypic characteristics of early-onset chronic obstructive pulmonary disease (COPD) in individuals under 50 are not well-defined.
  • Understanding early COPD is crucial for timely diagnosis and intervention, as it impacts younger populations.
  • Current knowledge gaps hinder effective management strategies for this demographic.

Purpose of the Study:

  • To describe the phenotypic characteristics of early COPD.
  • To compare early COPD cases with age-matched smokers having normal spirometry (controls).
  • To validate findings against existing large cohorts like ECLIPSE and COPDGene.

Main Methods:

  • Prospective, multicentre, case-control study design.
  • Inclusion of 92 early COPD cases (post-bronchodilator FEV1/FVC <0.7) and 197 controls.
  • Comparison with participants from ECLIPSE and COPDGene cohorts with similar criteria.

Main Results:

  • Early COPD cases exhibited moderate airflow limitation (FEV1 71.3±20.8%) with frequent symptoms and healthcare utilization.
  • Significant findings included air trapping (RV 150.6±55.5% ref.), reduced diffusing capacity (DLCO 84.2±20.7% ref.), and CT-detected emphysema (61%).
  • Less than half (46%) of early COPD cases were previously diagnosed; many reported family respiratory history and early-life hospitalizations.

Conclusions:

  • Early COPD is associated with substantial health impact and significant lung abnormalities, often remaining undiagnosed.
  • A notable proportion of early COPD patients report family history and early-life respiratory events, suggesting a potential early-life origin.
  • Further research into early-life factors is warranted to understand and potentially prevent COPD development.