Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.5K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.2K
3.2K
Types of RNA01:20

Types of RNA

8.5K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
8.5K
Types of RNA01:23

Types of RNA

71.5K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
71.5K
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

14.2K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
14.2K
Nucleic Acid Structure01:25

Nucleic Acid Structure

8.1K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
8.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Template-based RNA structure prediction advanced through a blind code competition.

bioRxiv : the preprint server for biology·2026
Same author

Dynamic assembly of a large multidomain ribozyme visualized by cryo-electron microscopy.

Nature communications·2025
Same author

Functional Relevance of CASP16 Nucleic Acid Predictions as Evaluated by Structure Providers.

Proteins·2025
Same author

Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers.

bioRxiv : the preprint server for biology·2025
Same author

biGMamAct: efficient CRISPR/Cas9-mediated docking of large functional DNA cargoes at the <i>ACTB</i> locus.

Synthetic biology (Oxford, England)·2025
Same author

On the Power and Challenges of Atomistic Molecular Dynamics to Investigate RNA Molecules.

Journal of chemical theory and computation·2024

Related Experiment Video

Updated: Dec 6, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.0K

The molecular structure of long non-coding RNAs: emerging patterns and functional implications.

Isabel Chillón1, Marco Marcia1

  • 1European Molecular Biology Laboratory (EMBL) Grenoble, Grenoble, France.

Critical Reviews in Biochemistry and Molecular Biology
|October 12, 2020
PubMed
Summary

Long non-coding RNAs (lncRNAs) have complex structures that determine their cellular functions and disease relevance. Visualizing these 3D shapes is key to understanding lncRNA mechanisms and developing future research strategies.

Keywords:
RNA chemical probingRNA evolutionRNA protein interactionsRNA secondary and tertiary structureRNA triple helixkissing loopspseudoknotsright-turnsstructural biology

More Related Videos

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture
10:34

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture

Published on: July 22, 2016

24.2K
Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
07:24

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Published on: July 9, 2021

2.6K

Related Experiment Videos

Last Updated: Dec 6, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.0K
Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture
10:34

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture

Published on: July 22, 2016

24.2K
Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
07:24

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Published on: July 9, 2021

2.6K

Area of Science:

  • Molecular Biology
  • Genomics
  • Structural Biology

Background:

  • Long non-coding RNAs (lncRNAs) are critical regulators of cellular processes and disease.
  • lncRNAs exhibit significant molecular complexity and distinct structural motifs.
  • Recent advancements have enabled visualization of full-length, native lncRNA 3D structures.

Purpose of the Study:

  • To review experimentally determined lncRNA structures.
  • To highlight the structure-function relationship of lncRNAs.
  • To discuss future directions for lncRNA structural characterization.

Main Methods:

  • Experimental determination of lncRNA structures.
  • Integration of computational, biochemical, and biophysical approaches.
  • Analysis of lncRNA 3D shape and topology.

Main Results:

  • lncRNA structures are visualized for the first time.
  • lncRNA structure dictates function.
  • Synergistic approaches are essential for structural characterization.

Conclusions:

  • Understanding lncRNA structure is crucial for elucidating their functions.
  • Overcoming challenges in lncRNA structural analysis is necessary for future research.
  • Detailed understanding of lncRNA molecular mechanisms is the ultimate goal.