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Updated: Dec 6, 2025
06:41
Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
Published on: October 24, 2018
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Intoxication and overdose should not preclude veno-venous extracorporeal membrane oxygenation
Jason S Radowsky1,2, Michael M Mazzeffi3, K Barry Deatrick1,4
1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Perfusion
|October 12, 2020
Summary
Veno-venous extracorporeal membrane oxygenation (VV ECMO) offers salvage therapy for severe respiratory failure due to acute intoxication. This study found no survival difference in patients needing VV ECMO for acute intoxication versus other causes.
Area of Science:
- Critical Care Medicine
- Toxicology
- Cardiopulmonary Support
Background:
- Acute intoxication (AI) contributes to rising morbidity and mortality in the US.
- Veno-venous extracorporeal membrane oxygenation (VV ECMO) is a critical intervention for severe respiratory failure in AI patients.
- Evaluating VV ECMO outcomes in AI patients is essential for optimizing care.
Purpose of the Study:
- To assess the outcomes of patients requiring VV ECMO for acute intoxication.
- To compare AI patients with those requiring VV ECMO for other critical conditions.
Main Methods:
- Retrospective review of 189 patients admitted to a VV ECMO unit (August 2014-August 2018).
- Stratification into AI and non-AI groups based on VV ECMO indication.
- Analysis of demographics, pre-cannulation data, ECMO parameters, and survival outcomes.
Main Results:
- 27 patients (14%) had AI as the indication for VV ECMO.
- AI patients were younger with lower BMI and PaO2/FiO2, and higher RESP scores.
- No significant differences in survival to discharge, ECMO duration, or hospital stay between groups.
Conclusions:
- VV ECMO provides comparable survival benefits for acute intoxication patients as for other indications.
- AI patients requiring VV ECMO should receive this life-saving therapy when indicated.
- Addressing potential stigma in referral acceptance for AI patients is crucial.
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