Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New trends in CLL treatment.

P Travade, C Chastang, G Dighiero

    Blood Cells
    |January 1, 1987
    PubMed
    Summary

    Treatment for chronic lymphocytic leukemia (CLL) remains evolving. While advanced stages show progress with regimens like CHOP, optimal treatments for early stages and specific modalities require further investigation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Monoclonal and/or Oligoclonal Immunoglobulins in Sera of Patients with Non-Hodgkin's Lymphomas, Determined by Iso-Electric Focusing and Immunoblotting.

    Leukemia & lymphoma·2016
    Same author

    B Cell Malignancies Frequently Target the Autoreactive B Cell Repertoire.

    Leukemia & lymphoma·2016
    Same author

    Proposals for a Phenotypic Classification of B-Chronic Lymphocytic Leukemia, Relationship with Prognostic Factors.

    Leukemia & lymphoma·2016
    Same author

    Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation.

    Leukemia·2014
    Same author

    "Role of the B-cell receptor and the microenvironment in chronic lymphocytic leukemia''.

    Blood cancer journal·2013
    Same author

    Lipoprotein lipase expression in unmutated CLL patients is the consequence of a demethylation process induced by the microenvironment.

    Leukemia·2012

    Area of Science:

    • Hematology
    • Oncology
    • Clinical Medicine

    Background:

    • Chronic lymphocytic leukemia (CLL) is a heterogeneous hematologic malignancy.
    • Various treatment modalities have been explored for CLL management.
    • Prognostic staging (A, B, C) guides therapeutic decisions.

    Purpose of the Study:

    • To review and analyze the outcomes of different treatment modalities for CLL patients.
    • To evaluate the efficacy of current treatments across various disease stages.
    • To identify areas for further research in CLL therapy.

    Main Methods:

    • Review of existing data on chemotherapy, radiotherapy, splenectomy, leukapheresis, and immunomodulatory agents.
    • Analysis of treatment results based on CLL staging (A, B, C).
    • Inclusion of data from cooperative groups like the Société Française d'Hématologie.

    Main Results:

    • Treatment decisions for Stage A CLL remain unclear.
    • Chlorambucil is a benchmark treatment for Stage B CLL, with no superior alternative identified.
    • The CHOP regimen shows promise for advanced Stage C CLL, particularly with low-dose adriamycin.

    Conclusions:

    • Further research is needed to clarify treatment strategies for early-stage CLL.
    • Ongoing trials are evaluating radiotherapy, splenectomy, and immunomodulators (levamisole, interleukins, interferons, monoclonal antibodies).
    • Conclusive evidence for novel therapies in CLL is still pending.

    Related Experiment Videos